At a glance
- What the study gets you
- Health checks and monitoring — no treatment given
- Type of study
- Observational (no treatment given)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Gene panel array (diagnostic test), Blood Sample Collection (other)
- How long the study runs
- Study runs about 40 months (dates as stated)
- About the drug or intervention
- Gene panel array — diagnostic test: Blood sample collection for gene panel testing · Blood Sample Collection — other: Blood sample collection for research purposes
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Observing health over time
- Ages
- 16 Years and over
- Who
- All
- Number of participants
- 100
- Started
- 2024-08-15
- Last checked
- 2026-03
Plain English Summary
What is this study?
- • Testing a new treatment for cancer of unknown primary
- • Clinical study - 100 participants
- • Cancer of Unknown Primary (CUP) is where cancer cells are found in the body but the place the cancer began is not known
Who can take part?
- • Ages 16 Years and over
- • Diagnosed with cancer of unknown primary
Where?
- • Manchester - The Christie NHS Foundation Trust
- • Liverpool - The Clatterbridge Cancer Centre NHS Foundation Trust
- • Blackpool - Blackpool Teaching Hospitals NHS Foundation Trust
- • Manchester - Northern Care Alliance NHS Foundation Trust
- • +2 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Cancer of Unknown Primary (CUP) is where cancer cells are found in the body but the place the cancer began is not known. It is the 6th leading cause of cancer death in the UK and the prognosis is poor with a median survival of 6-9 months. There is a higher than average incidence of CUP in the North West (NW) of England (population of 7.4 million). Precision medicine has transformed treatment strategies in known tumour types, however in CUP there remains an urgent need to better understand CUP molecular characteristics to establish potential roles for novel therapeutic strategies. Treatment options remain limited due to difficulties in determining the primary site of the tumour and the lack of access to validated biomarkers. Access to good-quality tissue for molecular profiling remains a huge challenge in CUP. The emergence of liquid biopsies (sequence DNA in a blood test) as a source of biomarkers is also gaining rapid ground and this study aims to explore the potential utility of liquid biopsies in CUP.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 16 Years and over
- Who can join: All genders
- How fit you need to be: ECOG 0 or better
What the study is looking for
- ✓Aged 16 years or over
- ✓Written agreement to take part according to ICH/GCP and national regulations
- ✓ECOG Performance status 0-2
- ✓Confirmed diagnosis of CUP as per the ESMO guidelines. Patients must have;
- ✓The local pathology reports confirming compatibility with CUP diagnosis and the associated slides used for the diagnosis
Who cannot take part
- ✗Patient with an immunohistochemistry profile that provides a definitive clinical indication of a primary cancer with...
- ✗Known HIV, Hepatitis B, C positive, due to the difficulties in handling high-risk specimens
- ✗Patients who are unable to provide fully informed written consent
- ✗Presence of any medical, psychological, familial or sociological condition that, in the investigator's opinion, will...
- ✗Bleeding diathesis (patients' on anticoagulation are permitted to enter the trial if anticoagulation can be safely...
See the full criteria
Where Is This Study? (6 UK sites)
The Christie NHS Foundation Trust
Manchester M20 4BX, United Kingdom
The Clatterbridge Cancer Centre NHS Foundation Trust
Liverpool, United Kingdom
Blackpool Teaching Hospitals NHS Foundation Trust
Blackpool, United Kingdom
Northern Care Alliance NHS Foundation Trust
Manchester, United Kingdom
University Hospitals of Morecambe Bay NHS Trust
Morecambe, United Kingdom
Lancashire Teaching Hospitals NHS Foundation Trust
Preston, United Kingdom
How to Get in Touch
EGG CUP Study Team
Sponsor contactCONTACT