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Study finishedN/A

Sweet Thresholds in Healthy Volunteers Study

Sponsor: Ranvier Health Ltd

NCT ID: NCT06697847

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Health checks and monitoring — no treatment given
Type of study
Observational (no treatment given)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
Not specified by the sponsor
How long the study runs
Study runs about 4 months (dates as stated)
About the drug or intervention
Not specified by the sponsor
Patient visit burden
Not specified by the sponsor
Type of study
Observing health over time
Ages
18 Years and over
Who
All
Number of participants
30
Started
2024-11-27
Last checked
2026-06

Plain English Summary

What is this study?

  • • Testing a new treatment for taste thresholds in healthy volunteers
  • • Clinical study - 30 participants
  • • The sweet threshold (concentration of sucrose in water) at which healthy participants can detect a sweet flavour will be recorded

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with taste thresholds in healthy volunteers

Where?

  • • Bristol - Westbury Lodge, Westbury Park

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The sweet threshold (concentration of sucrose in water) at which healthy participants can detect a sweet flavour will be recorded.

More detail

The sweet threshold (concentration of sucrose in water) at which healthy participants can detect a sweet flavour will be recorded by means of application on a cotton bud to the anterior third of the tongue. Solutions will be presented in a pseudo-randomised order. Mood questionnaires will be completed (to check that participants are indeed healthy). The questionnaires used will be the Patient Health Questionnaire 9 (PHQ9), Beck's Depression Inventory (BDI) and Generalised Anxiety Disorder Questionnaire 7 (GAD-7). This data is being collected with the intention of its use for comparison with sweet thresholds established in other populations using the same method of sweet threshold estimation.

Taste Thresholds in Healthy Volunteers

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What we know so far

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Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: All genders

What the study is looking for

  • ✓. Male and female adults of 18 years old and over;
  • ✓Participants without a diagnosis of major depressive disorder (MDD) / anxiety disorder;
  • ✓Participants not taking an antidepressant during the preceding 6 months
  • ✓Not suffering from significant other mental or physical illness, such as confirmed psychosis, end of life care, or...
  • ✓Willing and able to comply with all study-related procedures;

Who cannot take part

  • ✗Taking antidepressant medication currently or during the previous 6 months;
  • ✗Known or suspected hypersensitivity or intolerance to any taste testing solutions, or any of their excipients;
  • ✗Patients with a diagnosis of chronic pain;
  • ✗Pregnancy or possibility pregnancy, or breastfeeding;
  • ✗Participants using supplements containing psychoactive herbs (for example St Johns Wort or 5-HTP...
See the full criteria
Inclusion Criteria: . Male and female adults of 18 years old and over; * Participants without a diagnosis of major depressive disorder (MDD) / anxiety disorder; * Participants not taking an antidepressant during the preceding 6 months * Not suffering from significant other mental or physical illness, such as confirmed psychosis, end of life care, or any other condition assessed as significant by the Site Investigator; * Willing and able to comply with all study-related procedures; * Not having COVID 19 or continuing effects of COVID 19 including altered sense of taste; * Understands the study requirements and the treatment procedures and is able to provide written informed consent. Exclusion Criteria: * Taking antidepressant medication currently or during the previous 6 months; * Known or suspected hypersensitivity or intolerance to any taste testing solutions, or any of their excipients; * A history or presence of neurological or confounding psychiatric conditions (such as stroke, traumatic brain injury, epilepsy, space occupying lesions, multiple sclerosis, Parkinson's disease, vascular dementia, transient ischemic attack, or schizophrenia); * Patients with a diagnosis of chronic pain; * Pregnancy or possibility pregnancy, or breastfeeding; * Participants using supplements containing psychoactive herbs (for example St Johns Wort or 5-HTP (5-Hydroxytryptophan, also known as oxitriptan); * Participants regularly using psychoactive stimulants (for example MDMA); * Participants unable or unwilling to comply with study procedures.

Where Is This Study? (1 UK site)

Westbury Lodge, Westbury Park

Bristol BS6 7JE, United Kingdom

Data sourced from ClinicalTrials.gov · Last verified: 2026-06