At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Divarasib (drug), Pembrolizumab (drug), Pemetrexed (drug), Carboplatin (drug)
- How long the study runs
- Study runs about 60 months (dates as stated)
- About the drug or intervention
- Divarasib — drug: Divarasib will be administered orally QD · Pembrolizumab — drug: Pembrolizumab will be administered via IV infusion Q3W · Pemetrexed — drug: Pemetrexed will be administered via IV infusion Q3W · Carboplatin — drug: Carboplatin will be administered via IV infusion Q3W · Cisplatin — drug: Cisplatin will be administered via IV infusion Q3W
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 600
- Started
- 2025-10-24
- Last checked
- 2026-10
Plain English Summary
What is this study?
- • Testing a new treatment for non-small cell lung cancer
- • Phase3 - 600 participants
- • The purpose of this study is to evaluate the efficacy and safety of divarasib and pembrolizumab compared with pembrolizumab and pemetrexed and carboplatin or cisplatin, for the first-line treatment of adult participants with KRAS G12C-mutated, advanced or metastatic non squamous non-small cell lung cancer (NSCLC)
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with non-small cell lung cancer
Where?
- • Blackpool - Blackpool Teaching Hospitals NHS Foundation Trust , Victoria Hospital
- • Bristol - Bristol Haematology & Oncology Centre
- • Canterbury - East Kent Hospitals University NHS Foundation Trust
- • Cardiff - Velindre NHS Trust - Velindre Cancer Centre
- • +7 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The purpose of this study is to evaluate the efficacy and safety of divarasib and pembrolizumab compared with pembrolizumab and pemetrexed and carboplatin or cisplatin, for the first-line treatment of adult participants with KRAS G12C-mutated, advanced or metastatic non squamous non-small cell lung cancer (NSCLC).
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Biomarkers mentioned
Treatment history
Treatments you must have had:
- ✓ any other form of antineoplastic therapy while in the study
- ✓ KRAS G12C inhibit
What the study is looking for
- ✓activity scale (ECOG) performance status of 0 or 1
- ✓confirmed by testing a sample diagnosis of advanced or that has spread non squamous NSCLC that is not...
- ✓cancer that can be measured on scans, as defined by (standard scan measurements)
- ✓No prior systemic treatment for advanced or that has spread NSCLC
- ✓Documentation of the presence of a KRAS G12C mutation
See the full criteria
Where Is This Study? (11 UK sites)
Blackpool Teaching Hospitals NHS Foundation Trust , Victoria Hospital
Blackpool FY3 8NR, United Kingdom
Bristol Haematology & Oncology Centre
Bristol BS2 8ED, United Kingdom
East Kent Hospitals University NHS Foundation Trust
Canterbury CT1 3NG, United Kingdom
Caroline Cowley, Research & Innovation/Clinical Trials Unit Manager
ekhuft.researchandinnovation@nhs.net01227 783169Velindre NHS Trust - Velindre Cancer Centre
Cardiff CF14 2TL, United Kingdom
Hull University Teaching Hospitals NHS Trust
Hull HU3 2JZ, United Kingdom
James Illingworth
hyp-tr.development.research@nhs.net01482 461883 or 461903Barts and the London NHS Trust
London E1 2ES, United Kingdom
Royal Marsden Hospital - Fulham
London SW3 6JJ, United Kingdom
Sarah Cannon Research Institute
London W1G 6AD, United Kingdom
Maidstone and Tunbridge Wells NHS Trust
Maidstone ME16 9QQ, United Kingdom
Denise Day / Julie Knowles
mtw-tr.researchgovernance@nhs.net01622 225627Oxford University Hospitals NHS Trust - Churchill Hospital
Oxford OX3 7LE, United Kingdom
Royal Marsden NHS Foundation Trust
Sutton SM2 5PT, United Kingdom
How to Get in Touch
Reference Study ID Number: CO45042 https://forpatients.roche.com/ No attachments to email below.
Sponsor contactCONTACT
Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry
Sponsor contactCONTACT
