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Looking for participantsPhase3

A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis

Sponsor: Janssen Research & Development, LLC

NCT ID: NCT06807424

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Access to the study treatment being tested
Type of study
Interventional (receives a drug or procedure)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
Icotrokinra (drug), Placebo (drug)
How long the study runs
Study runs about 45 months (dates as stated)
About the drug or intervention
Icotrokinra — drug: Icotrokinra will be administered. · Placebo — drug: Placebo will be administered.
Patient visit burden
Not specified by the sponsor
Type of study
Testing a treatment
Ages
18 Years and over
Who
All
Number of participants
750
Started
2025-01-09
Last checked
2026-09

Plain English Summary

What is this study?

  • • Testing a new treatment for arthritis, psoriatic
  • • Phase3 - 750 participants
  • • The purpose of this study is to evaluate the efficacy of icotrokinra (JNJ-77242113) compared to placebo in biologic-experienced and biologic-naive participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with arthritis, psoriatic

Where?

  • • Barnet - Royal Free London NHS Foundation Trust
  • • Basingstoke - Basingstoke And North Hampshire Hospital
  • • Christchurch - University Hospitals Dorset NHS Foundation Trust
  • • Edinburgh - Western General Hospital
  • • +7 more UK sites

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The purpose of this study is to evaluate the efficacy of icotrokinra (JNJ-77242113) compared to placebo in biologic-experienced and biologic-naive participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA.

Arthritis, Psoriatic

How this trial compares with your answers

Answer 2 more questions to improve match

What we know so far

Condition· Matched your search
Age· Tell us your age for better matching
Gender· Tell us your sex for better matching

Still need:

  • • Tell us your age for better matching
  • • Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: All genders

Biomarkers mentioned

PsAhave a negativeand a negative

What the study is looking for

  • ✓Have a diagnosis of PsA for at least 3 months before the first administration of study intervention and meet...
  • ✓Have active plaque psoriasis with at least one psoriatic plaque of \>= 2 cm diameter or nail changes consistent with...

Who cannot take part

  • ✗Currently has a cancer or has a history of cancer within 5 years prior to screening
  • ✗Has known allergies, hypersensitivity, or intolerance to icotrokinra or its excipients
  • ✗Participants with fibromyalgia or osteoarthritis symptoms that, in the investigator's opinion, would have potential...
See the full criteria
Inclusion Criteria: * Have active psoriatic arthritis (PsA) despite current or previous use of greater than or equal to (\>=) 1 of the following: a. Non-biologic disease-modifying antirheumatic drug (DMARD) therapy; b. Apremilast therapy; c. Biologic-agent (limited to only 1) * Have a diagnosis of PsA for at least 3 months before the first administration of study intervention and meet classification criteria for Psoriatic Arthritis (CASPAR) at screening * Have active PsA as defined by: (a) At least 3 swollen joints and at least 3 tender joints at screening and at baseline (b) C-reactive protein (CRP) \>= 0.1 milligrams per deciliter (mg/dL) at screening from the central laboratory * Have at least 1 of the PsA subsets: distal interphalangeal joint involvement, polyarticular arthritis with absence of rheumatoid nodules, arthritis mutilans, asymmetric peripheral arthritis, or spondylitis with peripheral arthritis * Have active plaque psoriasis with at least one psoriatic plaque of \>= 2 cm diameter or nail changes consistent with psoriasis * A female participant of childbearing potential must have a negative highly sensitive serum pregnancy test (Beta-hCG) at screening and a negative urine pregnancy test at Week 0 prior to administration of study intervention Exclusion Criteria: * Has a history or current signs or symptoms of severe, progressive, or uncontrolled renal, hepatic, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic (with the exception of PsA), psychiatric, genitourinary, or metabolic disturbances * Currently has a malignancy or has a history of malignancy within 5 years prior to screening * Has known allergies, hypersensitivity, or intolerance to icotrokinra or its excipients * Has other inflammatory diseases that might confound the evaluations of benefit of icotrokinra therapy, including but not limited to rheumatoid arthritis (RA), systemic lupus erythematosus, or Lyme disease * Participants with fibromyalgia or osteoarthritis symptoms that, in the investigator's opinion, would have potential to interfere with efficacy assessments

Where Is This Study? (11 UK sites)

Royal Free London NHS Foundation Trust

Barnet EN5 3DJ, United Kingdom

Recruiting
Hospital R&D contact (matched)

Natasha Ajraam

rf-tr.randd@nhs.net020 375 82150

Basingstoke And North Hampshire Hospital

Basingstoke RG24 9NA, United Kingdom

Recruiting
Hospital R&D contact (matched)

Research Manager

research.team@hhft.nhs.uk01256 473202 Ext 4557

University Hospitals Dorset NHS Foundation Trust

Christchurch BH23 2JX, United Kingdom

Recruiting
Hospital R&D contact (matched)

Louise Bell

uhd.researchoffice@nhs.net0300 019 8500

Western General Hospital

Edinburgh EH4 2XU, United Kingdom

Recruiting
Hospital R&D contact (matched)

Dr Donna Noonan

gwh.researchmanagement@nhs.net01793 605565

Glasgow Royal Infirmary

Glasgow G31 2ER, United Kingdom

Recruiting
Hospital R&D contact (matched)

Colleen Bowthorpe

colleen.bowthorpe@nhs.scot01387 241815

Hereford County Hospital

Hereford HR1 2ER, United Kingdom

Recruiting

Forth Valley Royal Hospital

Larbert FK5 4WR, United Kingdom

Recruiting
Hospital R&D contact (matched)

Emma McDonough

fv.randd-depart@nhs.scot---

Haywood Hospital

Staffordshire ST6 7AG, United Kingdom

Recruiting

Torbay Hospital-Devon

Torquay TQ2 7AA, United Kingdom

Recruiting
Hospital R&D contact (matched)

Dr Fiona Roberts (R&D Director)

tsdft.research@nhs.net01803 656635

New Cross Hospital

Wolverhampton WV10 0QP, United Kingdom

Recruiting
Hospital R&D contact (matched)

Sarah Glover

rwh-tr.rdpmteam@nhs.net01902 695065

Betsi Cadwaladr University Health Board BCUHB

Wrexham LL13 7TD, United Kingdom

Recruiting
Hospital R&D contact (matched)

Lona Tudor Jones

BCU.research&development@wales.nhs.uk01352 718382

How to Get in Touch

Study Contact

Sponsor contact

CONTACT

844-434-4210 Participate-In-This-Study1@its.jnj.com
Data sourced from ClinicalTrials.gov · Last verified: 2026-09