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Ovarian Cancer Radiomics Approach in CT Led Evaluation

Sponsor: Imperial College Healthcare NHS Trust

NCT ID: NCT06817174

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Health checks and monitoring — no treatment given
Type of study
Observational (no treatment given)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
Not specified by the sponsor
How long the study runs
Study runs about 83 months (dates as stated)
About the drug or intervention
Not specified by the sponsor
Patient visit burden
Not specified by the sponsor
Type of study
Observing health over time
Ages
18 Years and over
Who
Female
Number of participants
168
Started
2025-02-10
Last checked
2025-06

Plain English Summary

What is this study?

  • • Testing a new treatment for ovarian cancer
  • • Clinical study - 168 participants
  • • When patients have suspected or confirmed ovarian cancer standard treatment will involve surgery and chemotherapy

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with ovarian cancer
  • • Female only

Where?

  • • London - Imperial College NHS Healthcare Trust

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

When patients have suspected or confirmed ovarian cancer standard treatment will involve surgery and chemotherapy. However, as with any treatment, it is challenging to predict treatment response in advance. Before treatment, all patients have a CT scan to describe where the cancer is in order to guide the treatment. There is now a new way to analyse routine scans using advanced computing methods, which may give more information about the ovarian cancer. This is called radiomics which analyses features in scans that are not visible to the naked eye. Our group at Imperial College London has worked on developing radiomic models to better understand ovarian cancer. This study aims to determine whether the information gained from this new approach would help us to tailor patient treatment plans to better meet the patient's individual needs, even more than done already. Furthermore, the aim is to understand how different types of ovarian cancer can correlate with the radiomic findings, which may help develop potential treatments in the future.

Ovarian Cancer

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What we know so far

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Still need:

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Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: Female only

What the study is looking for

  • ✓Written (signed and dated) agreement to take part
  • ✓Age 18 years or over
  • ✓Suspected or confirmed advanced epithelial ovarian cancer (FIGO stage 3B or more)
  • ✓Being considered for active anticancer treatment i.e. primary cytoreductive surgery followed by drug treatment or...
  • ✓Evaluable baseline portal venous phase CT scan prior to surgical or medical treatment for ovarian cancer

Who cannot take part

  • ✗Known contra-indication to CT with IV contrast (e.g. contrast allergy, kidney failure, inability to lie flat);
  • ✗Unable to give agreement to take part;
  • ✗Known pregnancy;
  • ✗No visible disease \<2cm on portal venous phase baseline CT scan;
  • ✗Previous surgery for resection of an adnexal mass;
See the full criteria
Inclusion Criteria: * Written (signed and dated) informed consent * Age 18 years or over * Suspected or confirmed advanced epithelial ovarian cancer (FIGO stage 3B or more) * Being considered for active anticancer treatment i.e. primary cytoreductive surgery followed by chemotherapy or neoadjuvant chemotherapy followed by interval cytoreductive surgery * Evaluable baseline portal venous phase CT scan prior to surgical or medical treatment for ovarian cancer * Disease visible on pre-treatment portal venous phase baseline CT scan (≥2cm) Exclusion Criteria: * Known contra-indication to CT with IV contrast (e.g. contrast allergy, renal failure, inability to lie flat); * Unable to give informed consent; * Known pregnancy; * No visible disease \<2cm on portal venous phase baseline CT scan; * Previous surgery for resection of an adnexal mass; * Significant artefact on CT image for example from metal prostheses that precluded meaningful segmentation of visible disease * Only fit for palliative care at initial presentation

Where Is This Study? (1 UK site)

Imperial College NHS Healthcare Trust

London, United Kingdom

Recruiting
Site contact (verified)

How to Get in Touch

Christina Fotopoulou, MD, PhD

Sponsor contact

CONTACT

(+44) +44 (0)20 3313 3274 c.fotopoulou@imperial.ac.uk
Data sourced from ClinicalTrials.gov · Last verified: 2025-06