At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Severe-energy restriction (other), Severe-energy restriction with exercise (other)
- How long the study runs
- Study runs about 33 months (dates as stated)
- About the drug or intervention
- Severe-energy restriction — other: The participants will receive only 25% of their estimated energy needs. · Severe-energy restriction with exercise — other: The participants will run on the treadmill for 30 minutes and receive 25% of their estimated energy needs.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years to 65 Years
- Who
- Male
- Number of participants
- 14
- Started
- 2025-07-30
- Last checked
- 2026-01
Plain English Summary
What is this study?
- • Testing a new treatment for healthy
- • NA - 14 participants
- • This study's primary aim is to investigate the acute effect of an exercise bout (30 minutes) on appetite and appetite-regulatory hormone responses during energy restriction
Who can take part?
- • Ages 18 Years to 65 Years
- • Diagnosed with healthy
- • Male only
Where?
- • Glasgow - New Lister Building, Glasgow Royal Infirmary
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
This study's primary aim is to investigate the acute effect of an exercise bout (30 minutes) on appetite and appetite-regulatory hormone responses during energy restriction. The researchers will also test if the exercise bout influences ad libitum energy intake after a period of energy restriction. The researchers will compare three groups (control, severe-energy restriction, and severe-energy restriction with exercise) to see if exercise bout, during energy restriction, affects appetite, appetite-regulatory hormones, and energy intake in healthy men.
More detail
Before the main experiments are conducted, participants will attend a screening visit where the participants will provide consent and complete questionnaires that assess their health, food preferences, and physical activity levels. Researchers will then measure the participants' height, weight, waist circumference, and body composition. Once the eligibility criteria are confirmed, participants will participate in two treadmill tests to establish their maximum oxygen uptake (V̇O2 max). After the screening visit, participants will participate in three main experiments, each lasting 24 hours: control, severe energy restriction, and severe energy restriction with exercise. These experiments will be conducted in a counterbalanced design. Each experiment will start around 9:30 AM, following an overnight fast of at least 10 hours. Participants will have a prescribed meal in the evening before each main experiment. After this meal, the participants are only allowed to drink water until the start of the main experiments. During the exercise trial, participants will begin by running on a treadmill for 30 minutes at a speed estimated to achieve 75% of their V̇O2 peak, followed by a rest period in the laboratory. The same protocol will be followed in the control and severe-energy trials, except that no exercise will be performed. Participants will rest in the laboratory during both the control and energy-restricted trials. In the control trial, the participants will receive 100% of their estimated energy needs; in the energy-restricted trials, the participants will receive only 25%. The participants will have standardized breakfast and lunch meals at 1h and 5h, respectively. At 24h, participants will be provided an ad libitum buffet meal in a private eating room. The researchers will assess appetite ratings in each experiment using 100 mm visual analog scales. The researchers will also collect blood samples to analyze ghrelin, peptide YY (PYY), glucagon-like peptide 1 (GLP-1), and potentially other blood-borne measures.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years - 65 Years
- Who can join: Male only
What the study is looking for
- ✓Males aged 18 years or older.
- ✓Have stable body mass for at least six months (within ±2 kg).
Who cannot take part
- ✗Females
- ✗People who are younger than 18 or older than 65 years old.
- ✗Following a special diet (e.g. weight loss, vegetarian or vegan, etc.).
- ✗Have food allergies related to the study.
- ✗Have significant contraindications to exercise (e.g., an injury that would inhibit running).
See the full criteria
Where Is This Study? (1 UK site)
New Lister Building, Glasgow Royal Infirmary
Glasgow, United Kingdom
How to Get in Touch
Sultan Alenezi, MSc
Sponsor contactCONTACT
James Dorling, PhD
Sponsor contactCONTACT