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Renal Perfusion and the Development of AKI Following Traumatic Injury

View on ClinicalTrials.gov ↗

At a glance

What the study gets you: Health checks and monitoring — no treatment given
Type of study: Observational (no treatment given)
Time in hospital: In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention: Ultrasound (including contrast enhanced ultrasound) (device), Sublingual incident dark field videomicroscopy (device), Urinary oxygen tension. (device)
How long the study runs: Study runs about 27 months (dates as stated)
About the drug or intervention: Ultrasound (including contrast enhanced ultrasound) — device: Ultrasound measures: contrast enhanced ultrasound (CEUS) of the kidney, venous excess ultrasound (VExUS), echocardiography · Sublingual incident dark field videomicroscopy — device: Sublingual incident dark field (IDF) videomicroscopy · Urinary oxygen tension. — device: Continuous urinary oxygen tension
Patient visit burden: Not specified by the sponsor

Type of study: Observing health over time
Ages: 18 Years and over
Who: All
Number of participants: 20
Started: 2024-04-13
Last checked: 2025-03

Plain English Summary

What is this study?

• Testing a new treatment for traumatic haemorrhagic shock
• Clinical study - 20 participants
• Acute kidney injury (AKI) is a complication of traumatic haemorrhagic shock (THS) and together these conditions increase mortality risk

Who can take part?

• Ages 18 Years and over
• Diagnosed with traumatic haemorrhagic shock

Where?

• London - King's College Hospital

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

Acute kidney injury (AKI) is a complication of traumatic haemorrhagic shock (THS) and together these conditions increase mortality risk. Although septic shock patients who develop severe AKI are known to develop hypoperfusion of the renal cortex, little is known regarding intra-renal perfusion changes in THS. The aim of the current study is to investigate the effects of THS on renal microcirculatory perfusion.

Traumatic Haemorrhagic ShockAKI (Acute Kidney Injury) Due to TraumaAKI - Acute Kidney Injury

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What we know so far

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Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

Age: 18 Years and over
Who can join: All genders

What the study is looking for

✓Age \> 18 years
✓Within 24 hours of ICU admission following traumatic injury
✓Received any blood products during initial resuscitation
✓Lactate \> 2 mmol/l at any stage prior to study enrolment

Who cannot take part

✗Known intolerance to Sonovue or any other ultrasound contrast agent
✗Patients with un-survivable injuries / not expected to survive 24 hours in whom the intent of treatment is palliative
✗Known CKD 4 or end stage kidney failure
✗Pregnancy

See the full criteria

Inclusion Criteria: * Age \> 18 years * Within 24 hours of ICU admission following traumatic injury * Received any blood products during initial resuscitation * Lactate \> 2 mmol/l at any stage prior to study enrolment Exclusion Criteria: * Known intolerance to Sonovue or any other ultrasound contrast agent * Patients with un-survivable injuries / not expected to survive 24 hours in whom the intent of treatment is palliative * Known CKD 4 or end stage renal failure * Pregnancy

Where Is This Study? (1 UK site)

King's College Hospital

London SE5 9RS, United Kingdom

Recruiting

Site contact (verified)

Sam Hutchings+442032994957 sam.hutchings@nhs.net

How to Get in Touch

Sam Hutchings

Sponsor contact

CONTACT

+442032994957 sam.hutchings@nhs.net

Data sourced from ClinicalTrials.gov · Last verified: 2025-03