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Looking for participantsPhase2

Platform Study to Evaluate the Efficacy and Safety of Investigational Compound(s) in Patients With Moderate to Severe Atopic Dermatitis

Sponsor: Novartis Pharmaceuticals

NCT ID: NCT06947993

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Access to the study treatment being tested
Type of study
Interventional (receives a drug or procedure)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
GHZ339 (drug), Placebo (drug)
How long the study runs
Study runs about 43 months (dates as stated)
About the drug or intervention
GHZ339 — drug: GHZ339 administered at dose A, B, C and D · Placebo — drug: Matching placebo
Patient visit burden
Not specified by the sponsor
Type of study
Testing a treatment
Ages
18 Years to 100 Years
Who
All
Number of participants
224
Started
2025-05-16
Last checked
2026-09

Plain English Summary

What is this study?

  • • Testing a new treatment for atopic dermatitis
  • • Phase2 - 224 participants
  • • This trial is designed to evaluate multiple compounds in participants with moderate to severe atopic dermatitis (AD)

Who can take part?

  • • Ages 18 Years to 100 Years
  • • Diagnosed with atopic dermatitis

Where?

  • • Dudley - Novartis Investigative Site
  • • Liverpool - Novartis Investigative Site
  • • London - Novartis Investigative Site

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

This trial is designed to evaluate multiple compounds in participants with moderate to severe atopic dermatitis (AD).

More detail

This is a multicenter, randomized, double-blind, placebo-controlled Phase II platform study to investigate the efficacy and safety of several interventions in participants with moderate to severe AD. The first intervention planned to be evaluated is GHZ339. Participants will be randomly assigned to one of the study arms.

Atopic Dermatitis

How this trial compares with your answers

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What we know so far

Condition· Matched your search
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Still need:

  • • Tell us your age for better matching
  • • Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years - 100 Years
  • Who can join: All genders

Treatment history

Treatments you must have had:

  • ✓ systemic corticosteroids (e

What the study is looking for

  • ✓Key Inclusion Criteria of the master protocol:
  • ✓Able and willing to sign the agreement to take part (IC)
  • ✓Patients with a diagnosis of AD and onset of disease for at least 1 year
  • ✓Moderate to severe AD
  • ✓Key Exclusion Criteria of the master protocol:
See the full criteria
Key Inclusion Criteria of the master protocol: * Able and willing to sign the informed consent (IC) * Patients with a diagnosis of AD and onset of disease for at least 1 year * Moderate to severe AD Key Exclusion Criteria of the master protocol: * Participants with a clinically significant medical condition or infectious disease (specified in sub-protocol) * Participants with clinically significant abnormal hematology, clinical chemistry, or urine test results or clinically significant abnormal ECG * Participant with any other active inflammatory skin disease * Participants with any chronic, uncontrolled medical condition, which would put the participant at increased risk during the study (e.g., uncontrolled: diabetes, hypertension) * Participants with any clinically unstable disease states that would likely require systemic corticosteroids (e.g., uncontrolled asthma) Additional inclusion and exclusion criteria may apply depending on the intervention specific requirements

Where Is This Study? (3 UK sites)

Novartis Investigative Site

Dudley DY1 2HQ, United Kingdom

SUSPENDED

Novartis Investigative Site

Liverpool L7 8XP, United Kingdom

ACTIVE_NOT_RECRUITING

Novartis Investigative Site

London SE1 9RT, United Kingdom

ACTIVE_NOT_RECRUITING

How to Get in Touch

Novartis Pharmaceuticals

Sponsor contact

CONTACT

1-888-669-6682 novartis.email@novartis.com

Novartis Pharmaceuticals

Sponsor contact

CONTACT

+41613241111
Data sourced from ClinicalTrials.gov · Last verified: 2026-09