At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Mezagitamab (drug)
- How long the study runs
- Study runs about 47 months (dates as stated)
- About the drug or intervention
- Mezagitamab — drug: Mezagitamab injection administered SC.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 150
- Started
- 2025-08-14
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for immune thrombocytopenic purpura (itp)
- • Phase3 - 150 participants
- • Primary immune thrombocytopenia (ITP) is a condition where the immune system mistakenly destroys platelets, which are cells that help stop bleeding
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with immune thrombocytopenic purpura (itp)
Where?
- • Leicester - University Hospitals of Leicester NHS Trust
- • Southampton - Southampton General Hospital
- • Southwark - Guy's Hospital - Guy's & St. Thomas NHS Foundation Trust
- • Liverpool - Royal Liverpool and Broadgreen University Hospitals NHS Trust
- • +6 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Primary immune thrombocytopenia (ITP) is a condition where the immune system mistakenly destroys platelets, which are cells that help stop bleeding. This leads to a lower number of platelets, making it easier to bruise or bleed. The main aim of this study is to check how safe mezagitamab is and how well it is tolerated by adults with chronic primary ITP, if given over a longer time. Other aims are to learn how effective treatment with mezagitamab is and how the body processes it (called pharmacokinetics or PK) over a longer time. Participants of the following previous mezagitamab studies will be invited to join this continuation study: TAK-079-3002 and TAK-079-1004. In this continuation study, participants will receive mezagitamab when certain protocol criteria are met. During the study, participants will visit their study clinic several times.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Biomarkers mentioned
Who cannot take part
- ✗For TAK-079-3002 participants:
- ✗1\. The participant has a history of severe allergic or anaphylactic reactions to recombinant proteins or excipients...
- ✗For TAK-079-1004 participants:
- ✗The participant has had any thrombotic or embolic event within 12 months before signing the ICF.
- ✗The participant has had a splenectomy within 3 months before signing the ICF.
See the full criteria
Where Is This Study? (10 UK sites)
University Hospitals of Leicester NHS Trust
Leicester LE1 5WW, United Kingdom
Southampton General Hospital
Southampton SO16 6YD, United Kingdom
Guy's Hospital - Guy's & St. Thomas NHS Foundation Trust
Southwark DE1 9RT, United Kingdom
Royal Liverpool and Broadgreen University Hospitals NHS Trust
Liverpool L7 8XP, United Kingdom
Greater Glasgow Health Board
Glasgow G312ER, United Kingdom
University Hospitals of North Midlands NHS Trust, Royal Stoke University Hospital
Stoke-on-Trent ST4 6QG, United Kingdom
Leeds Teaching Hospitals NHS Trust
Leeds LS9 TF, United Kingdom
Barts Health NHS Trust, Royal London Hospital
London E11BB, United Kingdom
University College London Hospitals
London NW1 2PG, United Kingdom
Imperial College Healthcare NHS Trust
London W12 0HS, United Kingdom
How to Get in Touch
Takeda Contact
Sponsor contactCONTACT
