At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Opevesostat (drug), Fludrocortisone/ Fludrocortisone acetate (drug), Dexamethasone/Dexamethasone acetate (drug), Rescue Medications (drug)
- How long the study runs
- Study runs about 27 months (dates as stated)
- About the drug or intervention
- Opevesostat — drug: Tablet for oral administration. · Fludrocortisone/ Fludrocortisone acetate — drug: Tablet for oral administration. · Dexamethasone/Dexamethasone acetate — drug: Tablet for oral administration. · Rescue Medications — drug: Hydrocortisone or hydrocortisone/hydrocortisone acetate administered via intramuscular injection as rescue medication. · Fulvestrant — drug: Administered via intramuscular injection. · Exemestane — drug: Tablet for oral administration. · Megestrol acetate/Medroxyprogesterone acetate — drug: Tablet for oral administration. · Tamoxifen — drug: Tablet for oral administration. · Letrozole — drug: Tablet for oral administration.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 250
- Started
- 2025-08-11
- Last checked
- 2026-10
Plain English Summary
What is this study?
- • Testing a new treatment for malignant neoplasm
- • Phase2 - 250 participants
- • Researchers want to learn if MK-5684 (the study medicine) can treat breast cancer, ovarian cancer, and endometrial cancer
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with malignant neoplasm
Where?
- • East Sussex - University Hospitals Sussex NHS Foundation Trust ( Site 2301)
- • Truro - The Royal Cornwall Hospital ( Site 2306)
- • London - St Bartholomew's Hospital ( Site 2302)
- • London - University College Hospital London ( Site 2303)
- • +4 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Researchers want to learn if MK-5684 (the study medicine) can treat breast cancer, ovarian cancer, and endometrial cancer. MK-5684, the study medicine, is designed to treat cancer by blocking the body from making steroid hormones. Researchers will compare MK-5684 to the standard treatments for each cancer type in this study. The goal of this study is to learn if people who receive MK-5684 live longer without the cancer growing or spreading compared to people who receive a standard treatment.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Biomarkers mentioned
Treatment history
Treatments you must have had:
- ✓ of platinum-based therapy in either the advanced/metastatic
- ✓ recovered to ≤Grade 1 or baseline
- ✓ well controlled HIV on antiretroviral therapy
What the study is looking for
- ✓The main inclusion criteria include but are not limited to the following:
- ✓Cohort A:
- ✓Cohort B:
- ✓Has received between 4 to 8 cycles of platinum-based doublet drug treatment in third-line (3L) setting for ovarian cancer.
- ✓Cohort C:
Who cannot take part
- ✗The main exclusion criteria include but are not limited to the following:
- ✗Cohort A:
- ✗Breast cancer amenable to treatment with curative intent.
- ✗Cohort B:
- ✗Is a candidate for curative-intent surgery or curative-intent radiotherapy for ovarian cancer.
See the full criteria
Where Is This Study? (8 UK sites)
University Hospitals Sussex NHS Foundation Trust ( Site 2301)
East Sussex BN2 1ES, United Kingdom
The Royal Cornwall Hospital ( Site 2306)
Truro TR1 3LJ, United Kingdom
St Bartholomew's Hospital ( Site 2302)
London EC1A 7BE, United Kingdom
University College Hospital London ( Site 2303)
London NW1 2PG, United Kingdom
Guy's & St Thomas' NHS Foundation Trust ( Site 2309)
London SE1 9RT, United Kingdom
Western General Hospital ( Site 2307)
Edinburgh EH4 2XU, United Kingdom
Queen Elizabeth Hospital ( Site 2305)
Birmingham B15 2GW, United Kingdom
The Christie NHS Foundation Trust ( Site 2300)
Manchester M20 4BX, United Kingdom
How to Get in Touch
Toll Free Number
Sponsor contactCONTACT
