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Proving Utility of a New Field-cycling MRI Prototype in Acute Stroke Patients

Sponsor: University of Aberdeen

NCT ID: NCT07004140

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Health checks and monitoring — no treatment given
Type of study
Observational (no treatment given)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
3T MRI research scan (other), Field-Cycling Imaging research scan (other), Follow up 3T MRI research scan (other), Follow up Field-Cycling Imaging research scan (other)
How long the study runs
Study runs about 8 months (dates as stated)
About the drug or intervention
3T MRI research scan — other: Baseline MRI scan · Field-Cycling Imaging research scan — other: Baseline FCI scan · Follow up 3T MRI research scan — other: Day 30 3T MRI scan · Follow up Field-Cycling Imaging research scan — other: Day 30 FCI scan · Blood samples for clotting experiments in vitro — other: Thrombi from whole blood from ischaemic stroke patients will be formed and examined using bench top nuclear magnetic resonance (NMR) assays.
Patient visit burden
Not specified by the sponsor
Type of study
Observing health over time
Ages
18 Years and over
Who
All
Number of participants
40
Started
2025-09-16
Last checked
2026-01

Plain English Summary

What is this study?

  • • Testing a new treatment for stroke acute
  • • Clinical study - 40 participants
  • • The goal of this study is to test if a new type of MRI scanner, called Field-Cycling Imaging (FCI), can show changes in the brain within the first day of a stroke due to a blocked blood vessel or bleeding in the brain

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with stroke acute

Where?

  • • Aberdeen - University of Aberdeen

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The goal of this study is to test if a new type of MRI scanner, called Field-Cycling Imaging (FCI), can show changes in the brain within the first day of a stroke due to a blocked blood vessel or bleeding in the brain. The main question it aims to answer is: • Can FCI identify brain tissue that might recover within the first few hours after a stroke begins? Participants will undergo a standard MRI scan and an FCI scan, as soon as possible after hospital admission. Participants who have had a blocked blood vessel will also provide a blood sample and will have a follow up visit at 30 days for repeat of both scans and providing another blood sample.

Stroke Acute

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What we know so far

Condition· Matched your search
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Still need:

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Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: All genders

What the study is looking for

  • ✓Acute stroke (\<24 hours from symptom onset).
  • ✓NIHSS ≥4 and \<25 with cortical involvement and/or large vessel occlusion on baseline imaging.
  • ✓Able to undergo 3T and FCI MRI \<24h of onset.
  • ✓With or without thrombolysis.

Who cannot take part

  • ✗Contraindications to MRI.
  • ✗Medically unstable.
  • ✗Unable to comprehend or comply with instructions regarding scanning
  • ✗Prior mRS of \>3.
  • ✗Identified for thrombectomy.
See the full criteria
Inclusion Criteria: * Acute stroke (\<24 hours from symptom onset). * NIHSS ≥4 and \<25 with cortical involvement and/or large vessel occlusion on baseline imaging. * Able to undergo 3T and FCI MRI \<24h of onset. * With or without thrombolysis. Exclusion Criteria: * Contraindications to MRI. * Medically unstable. * Unable to comprehend or comply with instructions regarding scanning * Prior mRS of \>3. * Identified for thrombectomy. * Non-stroke pathology or previous cortical infarct on CT scan \> 1/3 of middle cerebral artery territory.

Where Is This Study? (1 UK site)

University of Aberdeen

Aberdeen AB25 2ZD, United Kingdom

Recruiting
Site contact (verified)
Mary Joan MacLeod, PhDPrincipal Investigator

How to Get in Touch

Mary Joan MacLeod, PhD

Sponsor contact

CONTACT

+44 1224 437842 m.j.macleod@abdn.ac.uk

Gordon D Waiter, PhD

Sponsor contact

CONTACT

+44 1224 438356 g.waiter@abdn.ac.uk
Data sourced from ClinicalTrials.gov · Last verified: 2026-01