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PRecision biomArker-Guided MAnagement of TuberculosIs Contacts: a Discrete Choice Experiment

Sponsor: University College, London

NCT ID: NCT07024836

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Health checks and monitoring — no treatment given
Type of study
Observational (no treatment given)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
Not specified by the sponsor
How long the study runs
Study runs about 19 months (dates as stated)
About the drug or intervention
Not specified by the sponsor
Patient visit burden
Not specified by the sponsor
Type of study
Observing health over time
Ages
18 Years and over
Who
All
Number of participants
430
Started
2025-05-22
Last checked
2025-06

Plain English Summary

What is this study?

  • • Testing a new treatment for tuberculosis (tb)
  • • Clinical study - 430 participants
  • • This study is part of a broader programme of work to develop and pilot a randomised-controlled trial of new tests to identify people who will benefit most from preventive treatment for tuberculosis (TB)

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with tuberculosis (tb)

Where?

  • • London - Whittington Hospital

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

This study is part of a broader programme of work to develop and pilot a randomised-controlled trial of new tests to identify people who will benefit most from preventive treatment for tuberculosis (TB). The aim of the current study is to explore factors affecting patient decisions to start preventive treatment. The specific objectives are to understand how patients make decisions about preventive treatment initiation for TB (stage 1); and to design and conduct a "discrete choice experiment" survey to further evaluate preferences (stage 2).

More detail

We will perform up to 30 semi-structured interviews among people undergoing testing for latent TB infection, as part of routine clinical screening programmes (stage 1). Adults (aged ≥18 years) who have been or are being tested for LTBI in routine clinical services will be eligible for inclusion through purposive sampling. The findings from the qualitative study will then be used to inform the a discrete choice experiment (DCE). The DCE will be conducted to quantify the trade-off between future TB risk and preventive treatment acceptance, from patient and healthcare provided perspectives (stage 2).

Tuberculosis (TB)

How this trial compares with your answers

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What we know so far

Condition· Matched your search
Age· Tell us your age for better matching
Gender· Tell us your sex for better matching

Still need:

  • • Tell us your age for better matching
  • • Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: All genders

Who cannot take part

  • ✗Unable to provide agreement to take part.
See the full criteria
Inclusion Criteria: * Adults (aged ≥18 years) who have been tested for latent TB infection in routine clinical services, or are eligible for testing. Eligible people for testing include migrants from countries with high TB incidence (entered UK within 5 years), people with recent contact with a person with TB disease, and people eligible for LTBI screening prior to starting immunosuppression or through occupational health testing. Exclusion Criteria: * Unable to provide informed consent.

Where Is This Study? (1 UK site)

Whittington Hospital

London, United Kingdom

Recruiting
Site contact (verified)
Mahdad NoursadeghiPrincipal Investigator

How to Get in Touch

Rishi K Gupta, PhD

Sponsor contact

CONTACT

020 3549 5979 r.gupta@ucl.ac.uk
Data sourced from ClinicalTrials.gov · Last verified: 2025-06