Skip to main content
UK clinical trials - updated daily from ClinicalTrials.gov
TrialConnect
← Back to Search
Looking for participantsPhase2

Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Sponsor: Immunovant Sciences GmbH

NCT ID: NCT07032662

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Access to the study treatment being tested
Type of study
Interventional (receives a drug or procedure)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
Imeroprubart (drug), Placebo (drug)
How long the study runs
Study runs about 62 months (dates as stated)
About the drug or intervention
Imeroprubart — drug: Dose 1 subcutaneous (SC) once weekly (QW) for 24 weeks (Period 1) and 52 weeks (Period 2) · Placebo — drug: Matching placebo SC QW for 24 weeks (Period 1)
Patient visit burden
Not specified by the sponsor
Type of study
Testing a treatment
Ages
18 Years and over
Who
All
Number of participants
162
Started
2025-03-18
Last checked
2026-09

Plain English Summary

What is this study?

  • • Testing a new treatment for chronic inflammatory demyelinating polyneuropathy
  • • Phase2 - 162 participants
  • • This is a Phase 2b study to evaluate the efficacy and safety of Imeroprubart in adults with CIDP

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with chronic inflammatory demyelinating polyneuropathy

Where?

  • • Bristol - Site Number - 7001
  • • Glasgow - Site Number - 7002
  • • Salford - Site Number - 7000
  • • Southampton - Site Number - 7003

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

This is a Phase 2b study to evaluate the efficacy and safety of Imeroprubart in adults with CIDP.

More detail

This is a multi-center, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of Imeroprubart in adult participants with active CIDP.

Chronic Inflammatory Demyelinating Polyneuropathy

How this trial compares with your answers

Answer 2 more questions to improve match

What we know so far

Condition· Matched your search
Age· Tell us your age for better matching
Gender· Tell us your sex for better matching

Still need:

  • • Tell us your age for better matching
  • • Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: All genders

Biomarkers mentioned

met

What the study is looking for

  • ✓Have electrodiagnostic test results supporting the diagnosis of CIDP per the EAN/PNS guideline on diagnosis and...
  • ✓Additional inclusion criteria are defined in the protocol.

Who cannot take part

  • ✗Have current or prior history of IgM paraproteinemia with or without anti-myelin-associated-glycoprotein antibodies.
  • ✗Have distal, sensory, or focal CIDP, or have a diagnosis of autoimmune nodopathy per the EAN/PNS guideline on...
  • ✗Have polyneuropathy of causes other than CIDP including but not limited to:
  • ✗Multifocal motor neuropathy
  • ✗Hereditary demyelinating neuropathy
See the full criteria
Inclusion Criteria: * Have met clinical diagnostic criteria for typical CIDP (including incomplete typical CIDP) or one of the following CIDP variants: multifocal CIDP or motor CIDP per the 2021 European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) Guideline on Diagnosis and Treatment of CIDP. * Have electrodiagnostic test results supporting the diagnosis of CIDP per the EAN/PNS guideline on diagnosis and treatment of CIDP. * Are currently on, and have been receiving chronic, stable doses of systemic corticosteroids (i.e., daily or every other day oral or pulse regimen), or immunoglobulin therapy (IVIg or SCIg) ± corticosteroid therapy (either low dose oral corticosteroids or pulse corticosteroids) for at least 3 months for the treatment of CIDP at the time of the Screening Visit. Additional inclusion criteria are defined in the protocol. Exclusion Criteria: * Have current or prior history of IgM paraproteinemia with or without anti-myelin-associated-glycoprotein antibodies. * Have distal, sensory, or focal CIDP, or have a diagnosis of autoimmune nodopathy per the EAN/PNS guideline on diagnosis and treatment of CIDP. * Have polyneuropathy of causes other than CIDP including but not limited to: * Multifocal motor neuropathy * Hereditary demyelinating neuropathy * Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin change syndromes (i.e., POEMS) * Lumbosacral radiculoplexus neuropathy * Systemic illnesses including vitamin deficiency syndromes and paraneoplastic neuropathies * Drug- or toxin-induced * Have diabetes mellitus (DM) and meets any of the following criteria: * Does not have both typical CIDP and strong evidence of demyelination on nerve conduction study. * In the opinion of the Investigator, there is evidence of poorly controlled DM preceding the diagnosis of CIDP. * In the opinion of the Investigator, there is evidence of poorly controlled DM at screening. * Have a history of myelopathy or evidence of central demyelination. Additional exclusion criteria are defined in the protocol.

Where Is This Study? (4 UK sites)

Site Number - 7001

Bristol, United Kingdom

Recruiting

Site Number - 7002

Glasgow, United Kingdom

NOT_YET_RECRUITING

Site Number - 7000

Salford, United Kingdom

Recruiting

Site Number - 7003

Southampton, United Kingdom

Recruiting

How to Get in Touch

Study Contact

Sponsor contact

CONTACT

18007970414 clinicaltrials@immunovant.com
Data sourced from ClinicalTrials.gov · Last verified: 2026-09