At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- MK-2214 (biological), Placebo (drug)
- How long the study runs
- Study runs about 57 months (dates as stated)
- About the drug or intervention
- MK-2214 — biological: IV infusion · Placebo — drug: IV infusion
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 50 Years to 85 Years
- Who
- All
- Number of participants
- 340
- Started
- 2025-07-16
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for early alzheimer's disease
- • Phase2 - 340 participants
- • Researchers want to know if the study treatment called MK-2214 works to slow certain changes in the brains of people with Alzheimer's disease (AD)
Who can take part?
- • Ages 50 Years to 85 Years
- • Diagnosed with early alzheimer's disease
Where?
- • Aberdeen - Scottish Brain Sciences Aberdeen ( Site 8001)
- • Edinburgh - Scottish Brain Sciences ( Site 8000)
- • Southampton - Moorgreen Hospital ( Site 8004)
- • London - Leonard Wolfson Experimental Neurology Centre (LWENC) ( Site 8006)
- • +3 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Researchers want to know if the study treatment called MK-2214 works to slow certain changes in the brains of people with Alzheimer's disease (AD). AD is a type of dementia that can cause loss of memory, communication (such as speech), and decision-making skills. It can limit a person's ability to do daily tasks. MK-2214 is a study treatment designed to slow down AD. The goals of the study are to learn: * If MK-2214 slows the spread of tau in the brain compared to placebo. Tau is a protein that accumulates in AD \& damages brain cells. A placebo looks like the study treatment but has no study treatment in it. Using a placebo helps researchers better understand the effects of a study treatment. * About the safety of MK-2214 and if people tolerate it
More detail
Per AM03, an optional open-label extension period has been added to the study.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 50 Years - 85 Years
- Who can join: All genders
Treatment history
Treatments you must have had:
- ✓ been stable for 3 months
What the study is looking for
- ✓The main inclusion criteria include but are not limited to the following:
- ✓Has mild cognitive impairment (MCI) or mild dementia due to Alzheimer's Disease (AD)
- ✓Has a designated study partner who can fulfill the requirements of this study
- ✓If on an approved AD therapy for causing symptoms AD, the dosing regimen must have been stable for 3 months prior to...
Who cannot take part
- ✗The main exclusion criteria include but are not limited to the following:
- ✗Has a known history of stroke or cerebrovascular disease
- ✗Has diagnosis of a clinically relevant central nervous system disease other than AD or other condition that...
- ✗Has structural brain disease
- ✗Has a history of seizures or epilepsy within 5 years before screening
See the full criteria
Where Is This Study? (7 UK sites)
Scottish Brain Sciences Aberdeen ( Site 8001)
Aberdeen AB25 2XE, United Kingdom
Scottish Brain Sciences ( Site 8000)
Edinburgh EH12 5PJ, United Kingdom
Moorgreen Hospital ( Site 8004)
Southampton SO30 3JB, United Kingdom
Leonard Wolfson Experimental Neurology Centre (LWENC) ( Site 8006)
London NW1 2PG, United Kingdom
Warneford Hospital ( Site 8007)
Oxford OX3 7JX, United Kingdom
Remind UK ( Site 8003)
Bath BA1 3NG, United Kingdom
Re:Cognition Health - Birmingham ( Site 8002)
Birmingham B16 8LT, United Kingdom
How to Get in Touch
Toll Free Number
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