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Looking for participantsPhase2

A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)

Sponsor: Merck Sharp & Dohme LLC

NCT ID: NCT07033494

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Access to the study treatment being tested
Type of study
Interventional (receives a drug or procedure)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
MK-2214 (biological), Placebo (drug)
How long the study runs
Study runs about 57 months (dates as stated)
About the drug or intervention
MK-2214 — biological: IV infusion · Placebo — drug: IV infusion
Patient visit burden
Not specified by the sponsor
Type of study
Testing a treatment
Ages
50 Years to 85 Years
Who
All
Number of participants
340
Started
2025-07-16
Last checked
2026-09

Plain English Summary

What is this study?

  • • Testing a new treatment for early alzheimer's disease
  • • Phase2 - 340 participants
  • • Researchers want to know if the study treatment called MK-2214 works to slow certain changes in the brains of people with Alzheimer's disease (AD)

Who can take part?

  • • Ages 50 Years to 85 Years
  • • Diagnosed with early alzheimer's disease

Where?

  • • Aberdeen - Scottish Brain Sciences Aberdeen ( Site 8001)
  • • Edinburgh - Scottish Brain Sciences ( Site 8000)
  • • Southampton - Moorgreen Hospital ( Site 8004)
  • • London - Leonard Wolfson Experimental Neurology Centre (LWENC) ( Site 8006)
  • • +3 more UK sites

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

Researchers want to know if the study treatment called MK-2214 works to slow certain changes in the brains of people with Alzheimer's disease (AD). AD is a type of dementia that can cause loss of memory, communication (such as speech), and decision-making skills. It can limit a person's ability to do daily tasks. MK-2214 is a study treatment designed to slow down AD. The goals of the study are to learn: * If MK-2214 slows the spread of tau in the brain compared to placebo. Tau is a protein that accumulates in AD \& damages brain cells. A placebo looks like the study treatment but has no study treatment in it. Using a placebo helps researchers better understand the effects of a study treatment. * About the safety of MK-2214 and if people tolerate it

More detail

Per AM03, an optional open-label extension period has been added to the study.

Early Alzheimer's Disease

How this trial compares with your answers

Answer 2 more questions to improve match

What we know so far

Condition· Matched your search
Age· Tell us your age for better matching
Gender· Tell us your sex for better matching

Still need:

  • • Tell us your age for better matching
  • • Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 50 Years - 85 Years
  • Who can join: All genders

Treatment history

Treatments you must have had:

  • ✓ been stable for 3 months

What the study is looking for

  • ✓The main inclusion criteria include but are not limited to the following:
  • ✓Has mild cognitive impairment (MCI) or mild dementia due to Alzheimer's Disease (AD)
  • ✓Has a designated study partner who can fulfill the requirements of this study
  • ✓If on an approved AD therapy for causing symptoms AD, the dosing regimen must have been stable for 3 months prior to...

Who cannot take part

  • ✗The main exclusion criteria include but are not limited to the following:
  • ✗Has a known history of stroke or cerebrovascular disease
  • ✗Has diagnosis of a clinically relevant central nervous system disease other than AD or other condition that...
  • ✗Has structural brain disease
  • ✗Has a history of seizures or epilepsy within 5 years before screening
See the full criteria
Inclusion Criteria: The main inclusion criteria include but are not limited to the following: * Has mild cognitive impairment (MCI) or mild dementia due to Alzheimer's Disease (AD) * Has a designated study partner who can fulfill the requirements of this study * If on an approved AD therapy for symptomatic AD, the dosing regimen must have been stable for 3 months prior to screening Exclusion Criteria: The main exclusion criteria include but are not limited to the following: * Has a known history of stroke or cerebrovascular disease * Has diagnosis of a clinically relevant central nervous system disease other than AD or other condition that negatively impacts cognition or cognitive status chronically * Has structural brain disease * Has a history of seizures or epilepsy within 5 years before screening * Has any other major central nervous system trauma, or infections that affect brain function * Has major medical illness or unstable medical condition within 3 months before screening * Has a severe, acute, or chronic medical or psychiatric condition or laboratory abnormality * Has any immunological disease, which is not adequately controlled, or which requires treatment with biologics and/or immunosuppressants during the study * Has a bleeding disorder that is not under adequate control * Has a history of malignancy occurring within 5 years of screening * Has a risk factor for corrected QT interval (QTc) prolongation * Has liver disease * Is unwilling or unable to undergo computed tomography (CT), positron emission tomography (PET), or magnetic resonance imaging (MRI) scan * Resides in a nursing home or assisted care facility with need for direct continuous medical care and nursing supervision

Where Is This Study? (7 UK sites)

Scottish Brain Sciences Aberdeen ( Site 8001)

Aberdeen AB25 2XE, United Kingdom

Recruiting
Site contact (verified)
Study Coordinator+4401313530233

Scottish Brain Sciences ( Site 8000)

Edinburgh EH12 5PJ, United Kingdom

Recruiting
Site contact (verified)
Study Coordinator+4401313530233

Moorgreen Hospital ( Site 8004)

Southampton SO30 3JB, United Kingdom

Recruiting
Site contact (verified)
Study Coordinator+44 (0) 2382318757

Leonard Wolfson Experimental Neurology Centre (LWENC) ( Site 8006)

London NW1 2PG, United Kingdom

Recruiting
Site contact (verified)
Study Coordinator020 3448 4531

Warneford Hospital ( Site 8007)

Oxford OX3 7JX, United Kingdom

Recruiting
Site contact (verified)
Study Coordinator+441865902135

Remind UK ( Site 8003)

Bath BA1 3NG, United Kingdom

Recruiting
Site contact (verified)
Study Coordinator01225 476420

Re:Cognition Health - Birmingham ( Site 8002)

Birmingham B16 8LT, United Kingdom

Recruiting
Site contact (verified)
Study Coordinator0121 655 016

How to Get in Touch

Toll Free Number

Sponsor contact

CONTACT

1-888-577-8839 Trialsites@msd.com
Data sourced from ClinicalTrials.gov · Last verified: 2026-09