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Looking for participantsPhase3

TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Sponsor: Alnylam Pharmaceuticals

NCT ID: NCT07052903

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Access to the study treatment being tested
Type of study
Interventional (receives a drug or procedure)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
Nucresiran (drug), Sterile Normal Saline (0.9% NaCl) (drug)
How long the study runs
Study runs about 88 months (dates as stated)
About the drug or intervention
Nucresiran — drug: Nucresiran 300 mg administered SC q6M · Sterile Normal Saline (0.9% NaCl) — drug: Sterile Normal Saline (0.9% NaCl) administered SC once q6M
Patient visit burden
Not specified by the sponsor
Type of study
Testing a treatment
Ages
18 Years to 85 Years
Who
All
Number of participants
1,750
Started
2025-07-02
Last checked
2026-09

Plain English Summary

What is this study?

  • • Testing a new treatment for transthyretin amyloidosis with cardiomyopathy
  • • Phase3 - 1,750 participants
  • • The purpose of this study is to: * Evaluate the efficacy of nucresiran compared to placebo on reducing all-cause mortality and cardiovascular (CV) events * Evaluate the efficacy of nucresiran compared to placebo on additional assessments of CV events and/or death * Evaluate the efficacy of nucresiran compared to placebo on patient-reported health status and health-related quality of life

Who can take part?

  • • Ages 18 Years to 85 Years
  • • Diagnosed with transthyretin amyloidosis with cardiomyopathy

Where?

  • • Bellshill - Clinical Trial Site
  • • Birmingham - Clinical Trial Site
  • • Cardiff - Clinical Trial Site
  • • London - Clinical Trial Site
  • • +2 more UK sites

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The purpose of this study is to: * Evaluate the efficacy of nucresiran compared to placebo on reducing all-cause mortality and cardiovascular (CV) events * Evaluate the efficacy of nucresiran compared to placebo on additional assessments of CV events and/or death * Evaluate the efficacy of nucresiran compared to placebo on patient-reported health status and health-related quality of life

Transthyretin Amyloidosis With Cardiomyopathy

How this trial compares with your answers

Answer 2 more questions to improve match

What we know so far

Condition· Matched your search
Age· Tell us your age for better matching
Gender· Tell us your sex for better matching

Still need:

  • • Tell us your age for better matching
  • • Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years - 85 Years
  • Who can join: All genders

Biomarkers mentioned

or wild-typeeGFR

Treatment history

Treatments you must have had:

  • ✓ a diuretic

What the study is looking for

  • ✓Inclusion Criteria
  • ✓Has documented diagnosis of ATTR amyloidosis with cardiomyopathy including those with hereditary ATTR (hATTR) or...
  • ✓Has medical history of heart failure (HF) with at least 1 prior hospitalization for HF or signs and symptoms that...
  • ✓Patients may be receiving approved TTR stabilizers for ATTR amyloidosis (eg, tafamidis, acoramidis) and may be...
  • ✓Exclusion Criteria
See the full criteria
Inclusion Criteria * Has documented diagnosis of ATTR amyloidosis with cardiomyopathy including those with hereditary ATTR (hATTR) or wild-type ATTR (wATTR) amyloidosis. * Has medical history of heart failure (HF) with at least 1 prior hospitalization for HF or signs and symptoms that require treatment with a diuretic. * Has screening N-terminal prohormone B-type natriuretic peptide (NT-proBNP) \>300 ng/L and \<8500 ng/L; In patients with permanent or persistent atrial fibrillation, screening NT-proBNP \>600 ng/L and \<8500 ng/L. * Patients may be receiving approved TTR stabilizers for ATTR amyloidosis (eg, tafamidis, acoramidis) and may be receiving background therapy for HF at the discretion of the Investigator. Exclusion Criteria * Has New York Heart Association (NYHA) Class IV HF; or NYHA Class III heart failure AND ATTR Amyloidosis Disease Stage 3. * Has a polyneuropathy disability (PND) Score IIIa, IIIb, or IV. * Has an estimated glomerular filtration rate (eGFR) of \<30 mL/min/1.73m\^2 at screening. * Has received prior or currently receiving TTR-lowering therapy

Where Is This Study? (6 UK sites)

Clinical Trial Site

Bellshill ML4 3NJ, United Kingdom

Recruiting

Clinical Trial Site

Birmingham B15 2SQ, United Kingdom

Recruiting

Clinical Trial Site

Cardiff CF15 9SS, United Kingdom

Recruiting

Clinical Trial Site

London NW10 2PB, United Kingdom

Recruiting

Clinical Trial Site

London NW3 2QG, United Kingdom

Recruiting

Clinical Trial Site

Manchester M15 6SE, United Kingdom

Recruiting

How to Get in Touch

Clinical Trial Information Line

Sponsor contact

CONTACT

1-877-ALNYLAM clinicaltrials@alnylam.com

Clinical Trial Information Line

Sponsor contact

CONTACT

1-877-256-9526 clinicaltrials@alnylam.com
Data sourced from ClinicalTrials.gov · Last verified: 2026-09