At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Nucresiran (drug), Sterile Normal Saline (0.9% NaCl) (drug)
- How long the study runs
- Study runs about 88 months (dates as stated)
- About the drug or intervention
- Nucresiran — drug: Nucresiran 300 mg administered SC q6M · Sterile Normal Saline (0.9% NaCl) — drug: Sterile Normal Saline (0.9% NaCl) administered SC once q6M
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years to 85 Years
- Who
- All
- Number of participants
- 1,750
- Started
- 2025-07-02
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for transthyretin amyloidosis with cardiomyopathy
- • Phase3 - 1,750 participants
- • The purpose of this study is to: * Evaluate the efficacy of nucresiran compared to placebo on reducing all-cause mortality and cardiovascular (CV) events * Evaluate the efficacy of nucresiran compared to placebo on additional assessments of CV events and/or death * Evaluate the efficacy of nucresiran compared to placebo on patient-reported health status and health-related quality of life
Who can take part?
- • Ages 18 Years to 85 Years
- • Diagnosed with transthyretin amyloidosis with cardiomyopathy
Where?
- • Bellshill - Clinical Trial Site
- • Birmingham - Clinical Trial Site
- • Cardiff - Clinical Trial Site
- • London - Clinical Trial Site
- • +2 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The purpose of this study is to: * Evaluate the efficacy of nucresiran compared to placebo on reducing all-cause mortality and cardiovascular (CV) events * Evaluate the efficacy of nucresiran compared to placebo on additional assessments of CV events and/or death * Evaluate the efficacy of nucresiran compared to placebo on patient-reported health status and health-related quality of life
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years - 85 Years
- Who can join: All genders
Biomarkers mentioned
Treatment history
Treatments you must have had:
- ✓ a diuretic
What the study is looking for
- ✓Inclusion Criteria
- ✓Has documented diagnosis of ATTR amyloidosis with cardiomyopathy including those with hereditary ATTR (hATTR) or...
- ✓Has medical history of heart failure (HF) with at least 1 prior hospitalization for HF or signs and symptoms that...
- ✓Patients may be receiving approved TTR stabilizers for ATTR amyloidosis (eg, tafamidis, acoramidis) and may be...
- ✓Exclusion Criteria
See the full criteria
Where Is This Study? (6 UK sites)
Clinical Trial Site
Bellshill ML4 3NJ, United Kingdom
Clinical Trial Site
Birmingham B15 2SQ, United Kingdom
Clinical Trial Site
Cardiff CF15 9SS, United Kingdom
Clinical Trial Site
London NW10 2PB, United Kingdom
Clinical Trial Site
London NW3 2QG, United Kingdom
Clinical Trial Site
Manchester M15 6SE, United Kingdom
How to Get in Touch
Clinical Trial Information Line
Sponsor contactCONTACT
Clinical Trial Information Line
Sponsor contactCONTACT
