At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Semaglutide administration plus dietary counselling and physical activity encouragement (drug), Semaglutide plus a personalised and supervised program of resistance and endurance training (drug)
- How long the study runs
- Study runs about 35 months (dates as stated)
- About the drug or intervention
- Semaglutide administration plus dietary counselling and physical activity encouragement — drug: Semaglutide administration plus dietary counselling and physical activity encouragement · Semaglutide plus a personalised and supervised program of resistance and endurance training — drug: Semaglutide administration plus a personalised and supervised program of resistance and endurance training.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 20 Years to 75 Years
- Who
- All
- Number of participants
- 60
- Started
- 2025-08-01
- Last checked
- 2025-07
Plain English Summary
What is this study?
- • Testing a new treatment for diabetes mellitus type 2
- • NA - 60 participants
- • Traditional diabetes therapies focus on improving blood sugar control
Who can take part?
- • Ages 20 Years to 75 Years
- • Diagnosed with diabetes mellitus type 2
Where?
- • Aberdeen - Cardiac Research Office, Aberdeen Royal Infirmary
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Traditional diabetes therapies focus on improving blood sugar control. However, many studies show that this may not be enough. New treatments focusing on weight loss have heralded better results. One of these treatments is Semaglutide and the investigators wish to examine its effects further in this study. The investigators propose to investigate what happens to the fat inside the heart and the leg muscles.
More detail
Traditionally, diabetes therapies focus on improving glycaemic control. However, decades of well conducted clinical trials showed that glycaemic control alone has failed to reduce both all-cause and cardiovascular mortality in diabetes patients. The new diabetes treatment strategies of combining glucose control with weight reduction have heralded better cardiovascular outcomes, however their follow-up has been relatively short-term. The investigators propose to explore the effects of semaglutide administration plus dietary counselling and physical activity encouragement versus a more intensive strategy of semaglutide administration plus a personalised and supervised program of resistance and endurance exercise training.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 20 Years - 75 Years
- Who can join: All genders
Biomarkers mentioned
What the study is looking for
- ✓Patients with a confirmed diagnosis of type 2 diabetes established in the previous 10 years between the ages of 20...
- ✓HbA1c ≥ 53 mmol/mol (7%) typically on diet and/or metformin/sulphonylureas (and/or sodium-glucose cotransporter-2...
- ✓Patients who do not meet the WHO recommendations on physical activity (≤150 minutes per week) of moderate-vigorous...
- ✓Patients who have a BMI of ≥27 but with a body weight of less than 140kgs due to limitations of the scanner table...
- ✓Current or recent (within 3 months) eGFR \>30 mL/min/1.73m2)
Who cannot take part
- ✗Any previously unknown heart condition other than mild valvular disease
- ✗Any history of known coronary artery disease (including myocardial infarction and myocardial infarction with normal...
- ✗Any relevant or untreated endocrine condition (i.e. Cushings)
- ✗Impaired kidney function (defined as estimated glomerular filtration rate of less than 30 mL/min/1.73m2)
- ✗Blood pressure of more than 180/100 mmHg
See the full criteria
Where Is This Study? (1 UK site)
Cardiac Research Office, Aberdeen Royal Infirmary
Aberdeen AB25 2ZD, United Kingdom
How to Get in Touch
Alexander Davidson, DM
Sponsor contactCONTACT
Amelia E Rudd, MSc, PhD
Sponsor contactCONTACT
