At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Phase 1 - Maintenance Diet (other), Phase 2 - Weight loss diet (other)
- How long the study runs
- Study runs about 29 months (dates as stated)
- About the drug or intervention
- Phase 1 - Maintenance Diet — other: 3d maintenance diet (MT, fixed macronutrient composition of 15% protein, 30% fat and 55% CHO), fed to energy requirements (1.3 X RMR) · Phase 2 - Weight loss diet — other: 6 week calorie restricted high protein diet (CR, fixed macronutrient composition as 30% protein, 35% fat and 35% CHO) fed to energy requirements \[0.8 X Resting Metabolic Rate (RMR)\], with stepwise reduction of 100kcal/d at week 3 and 5
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years to 65 Years
- Who
- All
- Number of participants
- 75
- Started
- 2025-07-09
- Last checked
- 2025-07
Plain English Summary
What is this study?
- • Testing a new treatment for overweight and obese adults
- • NA - 75 participants
- • Obesity increases the risk of type 2 diabetes, cardiovascular disease, and certain cancers, primarily due to elevated abdominal fat storage
Who can take part?
- • Ages 18 Years to 65 Years
- • Diagnosed with overweight and obese adults
Where?
- • Aberdeen - Rowett Institute, University of Aberdeen
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Obesity increases the risk of type 2 diabetes, cardiovascular disease, and certain cancers, primarily due to elevated abdominal fat storage. With nearly two-thirds of the UK population living with overweight or obesity, there is an urgent necessity for evidence-based public health guidance to promote healthy weight. Calorie deficit can facilitate weight loss and body fat reduction, leading to health benefits, such as improved blood glucose control. Current weight management advice centres on lifestyle modification, incorporating changes to diet and physical activity to support a calorie deficit. However, existing dieting recommendations fail to consider gender or age. This is a surprising oversight, as it is well established that health outcomes vary significantly between men and women across the lifespan. Further, the menopause may have an impact on fat storage linked to changes in sex hormones. Our recent research, involving both mice and humans, has indicated that females are less responsive to weight loss and fat reduction during dieting. This study aims to understand endocrine and metabolic sex-based differences in obesity and calorie restriction, with a particular focus on women's health. We plan to conduct a diet study with 75 participants, encompassing both younger and older men and women, to monitor changes in energy expenditure and body composition using gold-standard techniques, such as doubly-labelled water. Blood and abdominal fat tissue samples will be collected to investigate how sex hormones might elucidate these differences. The aim of the study is to enhance our understanding of diet and women's health to combat obesity and promote healthy ageing.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years - 65 Years
- Who can join: All genders
Who cannot take part
- ✗Potential volunteers will be asked to fill in a health questionnaire at the screening visit to assess their...
- ✗Medication exclusion criteria, current use :-
- ✗Self-reported medical exclusion criteria:
- ✗Females who are planning to be pregnant, are pregnant or are breastfeeding
- ✗Anyone with coeliac disease or gluten intolerance or food allergy
See the full criteria
Where Is This Study? (1 UK site)
Rowett Institute, University of Aberdeen
Aberdeen, United Kingdom
How to Get in Touch
Alexandra M. Johnstone, Professor
Sponsor contactCONTACT
Marta Lonnie, Dr
Sponsor contactCONTACT