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A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489

View on ClinicalTrials.gov ↗

At a glance

What the study gets you: Access to the study treatment being tested
Type of study: Interventional (receives a drug or procedure)
Time in hospital: In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention: PF-07868489 (drug)
How long the study runs: Study runs about 33 months (dates as stated)
About the drug or intervention: PF-07868489 — drug: Participants will receive subcutaneous doses of PF-07868489 every 4 weeks
Patient visit burden: Not specified by the sponsor

Type of study: Testing a treatment
Ages: 18 Years and over
Who: All
Number of participants: 42
Started: 2025-11-10
Last checked: 2026-08

Plain English Summary

What is this study?

• Testing a new treatment for pulmonary hypertension
• Phase2 - 42 participants
• The purpose of this study is to learn about the long-term safety, tolerability and effects of the study medicine (PF-07868489) for the possible treatment of PAH

Who can take part?

• Ages 18 Years and over
• Diagnosed with pulmonary hypertension

Where?

• London - Hammersmith Hospital

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The purpose of this study is to learn about the long-term safety, tolerability and effects of the study medicine (PF-07868489) for the possible treatment of PAH. PAH is a condition in which there is high blood pressure in the arteries that carry blood from the heart to the lungs. This high pressure makes it harder for the heart to pump blood through those lungs, potentially damaging the right side of the heart. This is an open-label study. Which means that both the healthcare providers and the study participants are aware of the medicine being given. This study is also an extension study with study medicine (PF-07868489). An extension study allows patients from an earlier clinical study (also called as qualifying study) to continue participating to assess long-term benefits and safety of the medicine.

Pulmonary Hypertension

How this trial compares with your answers

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What we know so far

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Still need:

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Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

Age: 18 Years and over
Who can join: All genders

Treatment history

Treatments you must have had:

✓ treatment duration with PF-07868469 and other assessments at the end of that study

What the study is looking for

✓This study is seeking participants who are:
✓aged 18 years or older at screening of the previous study and completed the required treatment duration with...
✓willing and able to abide with all scheduled visits, treatment plan, laboratory tests, lifestyle considerations, and...
✓do not have worsening or hospitalization for worsening PAH during the qualifying study.
✓not on placement for a surgery to replace any tissue or part of the body (transplant), and planned surgery for PAH.

See the full criteria

This study is seeking participants who are: * aged 18 years or older at screening of the previous study and completed the required treatment duration with PF-07868469 and other assessments at the end of that study. * willing and able to abide with all scheduled visits, treatment plan, laboratory tests, lifestyle considerations, and other study procedures. * do not have worsening or hospitalization for worsening PAH during the qualifying study. * not on placement for a surgery to replace any tissue or part of the body (transplant), and planned surgery for PAH. * do not have an ongoing major health issue in the qualifying study, which in the opinion of the study doctor could make the participant not qualify for this study. * not suffering from or in the past have suffered from hepato-pulmonary syndrome (liver-related lung problem). * not currently prescribed or taking medicines called as GLP-1 agonist.

Where Is This Study? (1 UK site)

Hammersmith Hospital

London W12 0HS, United Kingdom

Data sourced from ClinicalTrials.gov · Last verified: 2026-08