Skip to main content
UK clinical trials - updated daily from ClinicalTrials.gov
TrialConnect
← Back to Search
ACTIVE NOT RECRUITINGPhase3

A Study to Evaluate Tobevibart+Elebsiran in Participants With Chronic HDV Infection Not Virologically Suppressed With Bulevirtide

Sponsor: Vir Biotechnology, Inc.

NCT ID: NCT07128550

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Access to the study treatment being tested
Type of study
Interventional (receives a drug or procedure)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
Tobevibart (drug), Elebsiran (drug), Bulevirtide (drug)
How long the study runs
Study runs about 72 months (dates as stated)
About the drug or intervention
Tobevibart — drug: Tobevibart administered by subcutaneous injection · Elebsiran — drug: Elebsiran administered by subcutaneous injection · Bulevirtide — drug: Bulevirtide administered by subcutaneous injection
Patient visit burden
Not specified by the sponsor
Type of study
Testing a treatment
Ages
18 Years to 70 Years
Who
All
Number of participants
150
Started
2025-07-30
Last checked
2026-07

Plain English Summary

What is this study?

  • • Testing a new treatment for viral hepatitis
  • • Phase3 - 150 participants
  • • This is a multicenter, open label, randomized Phase 3 clinical study to evaluate tobevibart + elebsiran in participants with Chronic HDV Infection not virologically suppressed with bulevirtide

Who can take part?

  • • Ages 18 Years to 70 Years
  • • Diagnosed with viral hepatitis

Where?

  • • London - Investigative Site
  • • London - Investigative Site
  • • London - Investigative Site
  • • Manchester - Investigative Site
  • • +1 more UK sites

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

This is a multicenter, open label, randomized Phase 3 clinical study to evaluate tobevibart + elebsiran in participants with Chronic HDV Infection not virologically suppressed with bulevirtide

Viral Hepatitis

How this trial compares with your answers

Answer 2 more questions to improve match

What we know so far

Condition· Matched your search
Age· Tell us your age for better matching
Gender· Tell us your sex for better matching

Still need:

  • • Tell us your age for better matching
  • • Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years - 70 Years
  • Who can join: All genders

What the study is looking for

  • ✓Male or female ages 18 to 70 years at screening
  • ✓HDV RNA ≥ 500 IU/mL at screening
  • ✓Receiving BLV 2 mg SC QD for ≥ 24 weeks at Day 1
  • ✓Noncirrhotic or compensated cirrhotic liver disease at screening
  • ✓On NRTI therapy against HBV for at least 12 weeks prior to day 1 or have HBV DNA \< 10 IU/ml at screening, currently...

Who cannot take part

  • ✗Serum liver enzymes ≥ 5 × ULN
  • ✗Any clinically significant chronic or acute medical or psychiatric condition that makes the participant unsuitable...
  • ✗History of significant liver disease from non-HBV or non-HDV etiology
  • ✗History of allergic reactions, hypersensitivity, or intolerance to the study treatment, its metabolites, or excipients.
  • ✗History of anaphylaxis
See the full criteria
Inclusion Criteria: 1. Male or female ages 18 to 70 years at screening 2. HDV RNA ≥ 500 IU/mL at screening 3. Receiving BLV 2 mg SC QD for ≥ 24 weeks at Day 1 4. Noncirrhotic or compensated cirrhotic liver disease at screening 5. On NRTI therapy against HBV for at least 12 weeks prior to day 1 or have HBV DNA \< 10 IU/ml at screening, currently on locally approved NRTI therapy Exclusion Criteria: 1. Serum ALT ≥ 5 × ULN 2. Any clinically significant chronic or acute medical or psychiatric condition that makes the participant unsuitable for participation. 3. History of significant liver disease from non-HBV or non-HDV etiology 4. History of allergic reactions, hypersensitivity, or intolerance to study drug, its metabolites, or excipients. 5. History of anaphylaxis 6. History of immune complex disease 7. History of autoimmune disorder 8. Current therapy or therapy within 24 weeks of screening with an immunomodulatory agent, immune checkpoint inhibitors, immunosuppressants, cytotoxic or chemotherapeutic agent, or chronic systemic corticosteroids.

Where Is This Study? (5 UK sites)

Investigative Site

London E1 1FR, United Kingdom

Investigative Site

London SE5 9NU, United Kingdom

Investigative Site

London W2 1NY, United Kingdom

Investigative Site

Manchester M8 5RB, United Kingdom

Investigative Site

Nottingham NG7 2UH, United Kingdom

Data sourced from ClinicalTrials.gov · Last verified: 2026-07