At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Tobevibart (drug), Elebsiran (drug), Bulevirtide (drug)
- How long the study runs
- Study runs about 72 months (dates as stated)
- About the drug or intervention
- Tobevibart — drug: Tobevibart administered by subcutaneous injection · Elebsiran — drug: Elebsiran administered by subcutaneous injection · Bulevirtide — drug: Bulevirtide administered by subcutaneous injection
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years to 70 Years
- Who
- All
- Number of participants
- 150
- Started
- 2025-07-30
- Last checked
- 2026-07
Plain English Summary
What is this study?
- • Testing a new treatment for viral hepatitis
- • Phase3 - 150 participants
- • This is a multicenter, open label, randomized Phase 3 clinical study to evaluate tobevibart + elebsiran in participants with Chronic HDV Infection not virologically suppressed with bulevirtide
Who can take part?
- • Ages 18 Years to 70 Years
- • Diagnosed with viral hepatitis
Where?
- • London - Investigative Site
- • London - Investigative Site
- • London - Investigative Site
- • Manchester - Investigative Site
- • +1 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
This is a multicenter, open label, randomized Phase 3 clinical study to evaluate tobevibart + elebsiran in participants with Chronic HDV Infection not virologically suppressed with bulevirtide
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years - 70 Years
- Who can join: All genders
What the study is looking for
- ✓Male or female ages 18 to 70 years at screening
- ✓HDV RNA ≥ 500 IU/mL at screening
- ✓Receiving BLV 2 mg SC QD for ≥ 24 weeks at Day 1
- ✓Noncirrhotic or compensated cirrhotic liver disease at screening
- ✓On NRTI therapy against HBV for at least 12 weeks prior to day 1 or have HBV DNA \< 10 IU/ml at screening, currently...
Who cannot take part
- ✗Serum liver enzymes ≥ 5 × ULN
- ✗Any clinically significant chronic or acute medical or psychiatric condition that makes the participant unsuitable...
- ✗History of significant liver disease from non-HBV or non-HDV etiology
- ✗History of allergic reactions, hypersensitivity, or intolerance to the study treatment, its metabolites, or excipients.
- ✗History of anaphylaxis
See the full criteria
Where Is This Study? (5 UK sites)
Investigative Site
London E1 1FR, United Kingdom
Investigative Site
London SE5 9NU, United Kingdom
Investigative Site
London W2 1NY, United Kingdom
Investigative Site
Manchester M8 5RB, United Kingdom
Investigative Site
Nottingham NG7 2UH, United Kingdom
