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Breast Cancer BRAs Study (Breast Cancer Biomechanics of Radiotherapy And Surgery)

Sponsor: Portsmouth Hospitals NHS Trust

NCT ID: NCT07135960

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Health checks and monitoring — no treatment given
Type of study
Observational (no treatment given)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
Not specified by the sponsor
How long the study runs
Study runs about 23 months (dates as stated)
About the drug or intervention
Not specified by the sponsor
Patient visit burden
Not specified by the sponsor
Type of study
Observing health over time
Ages
18 Years and over
Who
Female
Number of participants
45
Started
2025-02-06
Last checked
2026-09

Plain English Summary

What is this study?

  • • Testing a new treatment for breast cancer patients
  • • Clinical study - 45 participants
  • • This study, delivered by Portsmouth Hospitals University NHS Trust in conjunction with the Research Group in Breast Health at the University of Portsmouth \[1\], aims to assess whether it is possible to test breast biomechanics in women who have had surgery with or without radiotherapy for the treatment of breast cancer

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with breast cancer patients
  • • Female only

Where?

  • • Portsmouth - Queen Alexandra Hospital

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

This study, delivered by Portsmouth Hospitals University NHS Trust in conjunction with the Research Group in Breast Health at the University of Portsmouth \[1\], aims to assess whether it is possible to test breast biomechanics in women who have had surgery with or without radiotherapy for the treatment of breast cancer.

More detail

Breast cancer is an increasingly common condition, affecting \>56,000 women a year in the UK. Surgery and radiotherapy are commonly used to treat breast cancer. Both these treatments can affect the structure and movement of the breast tissue, which is collectively called breast biomechanics. Breast biomechanics has been studied in healthy women and in female athletes, and across the menstrual cycle, menopause and pregnancy. Investigators know from this research that breast biomechanics can affect the type of bra support women need, which when optimised can improve comfort and quality of life as well as reduce the potential for tissue damage. However, breast biomechanics and associated breast garment support requirements (bra support) have not yet been significantly investigated in women undergoing breast cancer treatment. Patients who would be eligible to participate in this study include women aged 18 or treated with surgery +/- radiotherapy for breast cancer that affects one of their breasts. Patients will be recruited from the Breast Unit at Queen Alexandra Hospital, Cosham. Participation in this study will involve attending the biomechanics testing laboratory at UoP after their surgery and/or after radiotherapy, and optionally before surgery too. 3D scans and sensors will be used to assess the structure and movement of the breast. Participants will be asked their views on the testing methods, as well as their bra requirements and exercise habits before and after breast cancer treatment. The information generated from this study could be used in the future to help design better bras for women treated for breast cancer. It could also help women make decisions about treatment based on evidence about how the breast is likely to move differently afterwards and improve satisfaction with treatment outcomes.

Breast Cancer Patients

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What we know so far

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Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: Female only

What the study is looking for

  • ✓Female
  • ✓18 years of age or above
  • ✓Early or that has grown locally breast cancer classified as B5a or B5b (radical treatment intent)
  • ✓Unilateral breast cancer (contralateral breast used as control)
  • ✓Receiving or has received breast cancer surgery

Who cannot take part

  • ✗that has spread breast cancer diagnosis
  • ✗\< 2 weeks post-operative
  • ✗\< 4 weeks post-radiotherapy
  • ✗Active post-operative breast infection
  • ✗Requirement of ongoing breast dressings
See the full criteria
Inclusion Criteria: * Female * 18 years of age or above * Early or locally advanced breast cancer classified as B5a or B5b (radical treatment intent) * Unilateral breast cancer (contralateral breast used as control) * Receiving or has received breast cancer surgery * +/- Adjuvant radiotherapy * Able to travel to the University of Portsmouth Breast biomechanics laboratory * Participant has capacity to consent. Exclusion Criteria: * Metastatic breast cancer diagnosis * \< 2 weeks post-operative * \< 4 weeks post-radiotherapy * Active post-operative breast infection * Requirement of ongoing breast dressings * Previous breast surgery to contralateral breast * Bilateral breast cancer * Epilepsy (due to strobe on 3D scanner) * Pregnancy or \<6 weeks post-partum * Breastfeeding * Rockwood Frailty score \>5 (or those unable to ambulate un-aided) * Requiring interpreter.

Where Is This Study? (1 UK site)

Queen Alexandra Hospital

Portsmouth PO6 3LY, United Kingdom

Recruiting
Hospital R&D contact (matched)

Joe Shoebridge

research.office@porthosp.nhs.uk023 9228 6236

How to Get in Touch

Amy Huseyin

Sponsor contact

CONTACT

02392 286000 Amyrose.Huseyin@porthosp.nhs.uk
Data sourced from ClinicalTrials.gov · Last verified: 2026-09