How do I find clinical trials in the UK?

Use TrialConnect to search by condition, location, or eligibility. We index over 29,000 UK clinical trials from ClinicalTrials.gov, updated daily. Enter your condition and we show matching trials near you.

Are there paid clinical trials in the UK?

Yes. Healthy volunteers can earn £500–£3,000 for Phase 1 and bioequivalence studies. TrialConnect lists paid research studies at UK research units in London, Leeds, Nottingham, and more.

What conditions have clinical trials available?

TrialConnect covers 41 conditions including breast cancer, lung cancer, diabetes, heart failure, COPD, multiple sclerosis, Parkinson's disease, Crohn's disease, and many more.

Is TrialConnect free?

Yes. TrialConnect is completely free for patients. We are not affiliated with the NHS or NIHR. Data is sourced from ClinicalTrials.gov.

Am I eligible for a clinical trial?

Each trial has specific eligibility criteria including age, condition, medical history, and current treatments. TrialConnect shows you trials that may match your situation, but only the trial team can confirm eligibility.

Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)

View on ClinicalTrials.gov ↗

At a glance

What the study gets you: Access to the study treatment being tested
Type of study: Interventional (receives a drug or procedure)
Time in hospital: In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention: Muvalaplin (drug), Placebo (drug)
How long the study runs: Study runs about 66 months (dates as stated)
About the drug or intervention: Muvalaplin — drug: Administered orally · Placebo — drug: Administered orally
Patient visit burden: Not specified by the sponsor

Type of study: Testing a treatment
Ages: 18 Years and over
Who: All
Number of participants: 10,450
Started: 2025-09-02
Last checked: 2026-09

Plain English Summary

What is this study?

• Testing a new treatment for elevated lp(a)
• Phase3 - 10,450 participants
• The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke

Who can take part?

• Ages 18 Years and over
• Diagnosed with elevated lp(a)

Where?

• Belfast - South Eastern Health and Social Care Trust
• Birmingham - FutureMeds - Birmingham
• Blackpool - Layton Medical Centre
• Bodelwyddan - Glan Clwyd Hospital
• +21 more UK sites

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The purpose of this study is to evaluate the efficacy of muvalaplin in reducing cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular disease or are at risk of a heart attack or stroke.

Elevated Lp(a)Atherosclerotic Cardiovascular Disease (ASCVD)

How this trial compares with your answers

Answer 2 more questions to improve match

What we know so far

Condition· Matched your search

Age· Tell us your age for better matching

Gender· Tell us your sex for better matching

Still need:

• Tell us your age for better matching
• Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

Age: 18 Years and over
Who can join: All genders

What the study is looking for

✓Have Lp(a) ≥175 nanomoles per liter (nmol/L)
✓Meet one of the following criteria:
✓Are at risk for a first ASCVD event, defined as one or more of the following:
✓Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without a history of...
✓A high coronary artery calcium (CAC) score

Who cannot take part

✗Are planning or expected to undergo a procedure to restore blood flow in the arteries or a major heart surgery...
✗Have uncontrolled high blood pressure
✗Have New York Heart Association (NYHA) class III or IV heart failure
✗Have undergone a procedure to remove cholesterol from the blood within 90 days of screening, or have a planned...
✗Have severe kidney impairment

See the full criteria

Inclusion Criteria: * Have Lp(a) ≥175 nanomoles per liter (nmol/L) * Meet one of the following criteria: * Have had a prior atherosclerotic cardiovascular disease (ASCVD) event (such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body) within 10 years prior to screening * Are at risk for a first ASCVD event, defined as one or more of the following: * Documented coronary artery disease (CAD), carotid stenosis, or peripheral artery disease (PAD) without a history of ASCVD event * A high coronary artery calcium (CAC) score * Reduced kidney function with diabetes * Combination(s) of high risk factors Exclusion Criteria: * Have experienced a major cardiovascular event or surgery, such as heart attack, stroke, or procedure to restore blood flow to the heart or other parts of the body, within 90 days prior to screening or occurring between screening and randomization * Are planning or expected to undergo a procedure to restore blood flow in the arteries or a major heart surgery during the study * Have uncontrolled high blood pressure * Have New York Heart Association (NYHA) class III or IV heart failure * Have undergone a procedure to remove cholesterol from the blood within 90 days of screening, or have a planned procedure during the study * Have severe kidney impairment * Have had cancer within 5 years prior to screening

Where Is This Study? (25 UK sites)

South Eastern Health and Social Care Trust

Belfast BT16 1RH, United Kingdom

Recruiting

Site contact (verified)

Patrick DonnellyPrincipal Investigator

FutureMeds - Birmingham

Birmingham B21 9RY, United Kingdom

NOT_YET_RECRUITING

Site contact (verified)

Imtisal Ul-HaqPrincipal Investigator

441215922050

Layton Medical Centre

Blackpool FY3 7EN, United Kingdom

Recruiting

Site contact (verified)

Rebecca ClarkPrincipal Investigator

441253951943

Glan Clwyd Hospital

Bodelwyddan LL18 5UJ, United Kingdom

Recruiting

Site contact (verified)

Satheesh Balakrishnan NairPrincipal Investigator

Bradford on Avon Health Centre

Bradford on Avon BA15 1DQ, United Kingdom

Recruiting

Site contact (verified)

Nell WyattPrincipal Investigator

01225866611

Bristol Royal Infirmary

Bristol BS2 8HW, United Kingdom

Recruiting

Site contact (verified)

Paul DowniePrincipal Investigator

0117 342 7769

FutureMeds - Liverpool

Bromborough CH62 6EE, United Kingdom

NOT_YET_RECRUITING

Site contact (verified)

Tamer YousefPrincipal Investigator

Panthera Biopartners - North London

Enfield EN3 4GS, United Kingdom

Recruiting

Site contact (verified)

Delphine NkulizaPrincipal Investigator

FutureMeds Glasgow - CPS Research

Glasgow G20 7BE, United Kingdom

Recruiting

Site contact (verified)

Kristen LaingPrincipal Investigator

0141 9467888

Panthera Biopartners - Glasgow

Glasgow G51 4RY, United Kingdom

Recruiting

Site contact (verified)

Charles BoylePrincipal Investigator

0141 4284318

Velocity Clinical Research, High Wycombe

High Wycombe HP11 2QW, United Kingdom

Recruiting

Site contact (verified)

Ronnie BebosoPrincipal Investigator

HMC Health Group - Meadows Centre for Health

Hounslow TW4 7NR, United Kingdom

Recruiting

Site contact (verified)

Ivor SinghPrincipal Investigator

07946732168

Raigmore Hospital

Inverness IV2 3UJ, United Kingdom

Recruiting

Site contact (verified)

Rosemary ClarkePrincipal Investigator

Panthera Biopartners - Keele

Keele ST5 5BG, United Kingdom

Recruiting

Site contact (verified)

Karen FaulknerPrincipal Investigator

Oak Tree Surgery

Liskeard PL14 3XA, United Kingdom

Recruiting

Site contact (verified)

Kate NorthridgePrincipal Investigator

FutureMeds - London

London NW10 2PB, United Kingdom

Recruiting

Site contact (verified)

Pembe OzunluPrincipal Investigator

07858413118

EMS Healthcare

Macclesfield SK10 4TF, United Kingdom

NOT_YET_RECRUITING

Site contact (verified)

Nicholas ProbertPrincipal Investigator

The Adam Practice

Poole BH16 5PW, United Kingdom

Recruiting

Site contact (verified)

Patrick MoorePrincipal Investigator

01202 339050

Panthera Biopartners - Preston

Preston PR2 9QB, United Kingdom

Recruiting

Site contact (verified)

Samin ChowdhuryPrincipal Investigator

01772237822

Panthera Biopartners - Manchester

Rochdale OL11 4AU, United Kingdom

Recruiting

Site contact (verified)

Amir AfzulPrincipal Investigator

01706436223

Panthera Biopartners - Sheffield

Sheffield S2 5FX, United Kingdom

Recruiting

Site contact (verified)

Hannah CollinsPrincipal Investigator

01143503730

FutureMeds Teesside - Middlefield Centre

Stockton-on-Tees TS19 8PE, United Kingdom

Recruiting

Site contact (verified)

Andreas HajineocliPrincipal Investigator

Rame Group Practice

Torpoint PL11 2TB, United Kingdom

Recruiting

Site contact (verified)

Lawrence BarnesPrincipal Investigator

(0044) 1752 817900

Sandwell General Hospital

West Bromwich B71 4HJ, United Kingdom

Recruiting

Site contact (verified)

Inessa TraceyPrincipal Investigator

01215073426

Panthera Clinic - York

York YO24 4LJ, United Kingdom

Recruiting

Site contact (verified)

Henrique FreitasPrincipal Investigator

01706 436278

How to Get in Touch

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or

Sponsor contact

CONTACT

1-317-615-4559 LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact

Sponsor contact

CONTACT

clinical_inquiry_hub@lilly.com

Data sourced from ClinicalTrials.gov · Last verified: 2026-09