At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Pasritamig (biological), Placebo (other), Best Supportive Care (BSC) (drug), JNJ-87189401 (biological)
- How long the study runs
- Study runs about 35 months (dates as stated)
- About the drug or intervention
- Pasritamig — biological: Pasritamig will be administrated through IV infusion. · Placebo — other: Placebo will be administrated through IV infusion. · Best Supportive Care (BSC) — drug: BSC will be administered at the discretion of the treating physician. · JNJ-87189401 — biological: JNJ-87189401 will be administered.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- Male
- Number of participants
- 1,203
- Started
- 2025-09-02
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for metastatic castration-resistant prostatic neoplasms
- • Phase3 - 1,203 participants
- • The purpose of this study is to evaluate the overall survival (length of time from the start of study to date of death from any cause) for pasritamig (JNJ-78278343) in Part 1 in combination with best supportive care (BSC) and in Part 2 with JNJ-87189401+BSC as compared to placebo with BSC in participants with metastatic castration-resistant prostate cancer (mCRPC; a stage of cancer that has spread beyond the prostate gland and is no longer responding to hormone therapies)
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with metastatic castration-resistant prostatic neoplasms
- • Male only
Where?
- • Birmingham - University Hospitals Birmingham NHS Foundation Trust
- • London - University College London Hospitals
- • Manchester - The Christie NHS Foundation Trust Christie Hospital
- • Sutton - Royal Marsden Hospital (Sutton)
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The purpose of this study is to evaluate the overall survival (length of time from the start of study to date of death from any cause) for pasritamig (JNJ-78278343) in Part 1 in combination with best supportive care (BSC) and in Part 2 with JNJ-87189401+BSC as compared to placebo with BSC in participants with metastatic castration-resistant prostate cancer (mCRPC; a stage of cancer that has spread beyond the prostate gland and is no longer responding to hormone therapies).
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: Male only
Biomarkers mentioned
Treatment history
Treatments you must have had:
- ✓ specifications include receipt of the following:
- ✓ progressed on at least 1 ARPI and unlikely to benefit from retreatment with another ARPI
- ✓ to have received at least 2 previous taxane-based regimens
- ✓ systemic immunosuppressive medications (eg, chronic corticosteroid, methotrexate, or tacrolimus)
What the study is looking for
- ✓Inclusion Criteria
- ✓confirmed by a biopsy adenocarcinoma of the prostate
- ✓PSA greater than or equal to (≥) 2 nanogram per milliliter (ng/mL) at screening
- ✓In the opinion of the investigator, the next best treatment option is a clinical trial
- ✓Androgen-receptor pathway inhibitor (ARPI): Must have progressed on at least 1 ARPI and unlikely to benefit from...
See the full criteria
Where Is This Study? (4 UK sites)
University Hospitals Birmingham NHS Foundation Trust
Birmingham B15 2TH, United Kingdom
University College London Hospitals
London WC1E 6BT, United Kingdom
Rajinder Sidhu - Associate Director, Research Governance and Operations
uclh.jro-communications@nhs.net020 3447 9825The Christie NHS Foundation Trust Christie Hospital
Manchester M20 4BX, United Kingdom
Royal Marsden Hospital (Sutton)
Sutton SM2 5PT, United Kingdom
How to Get in Touch
Study Contact
Sponsor contactCONTACT
