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Feasibility and Acceptability of Isometric Exercise and Lifestyle Change for the Management of Hypertension

View on ClinicalTrials.gov ↗

At a glance

What the study gets you: Access to the study treatment being tested
Type of study: Interventional (receives a drug or procedure)
Time in hospital: Mix of remote tasks and in-person visits
Drug or intervention: Isometric Exercise and Lifestyle Change Advice (behavioural), Lifestyle Change Advice (behavioural)
How long the study runs: Study runs about 24 months (dates as stated)
About the drug or intervention: Isometric Exercise and Lifestyle Change Advice — behavioural: The intervention consists of two distinct phases: • Intensive Phase (12 weeks) - a structured, high-support period involving three weekly supervised isometric exercise sessions and lifestyle change advice. · Lifestyle Change Advice — behavioural: Lifestyle change advice given as per current standard care for hypertension
Patient visit burden: Not specified by the sponsor

Type of study: Testing a treatment
Ages: 18 Years and over
Who: All
Number of participants: 70
Started: 2026-02-02
Last checked: 2026-01

Plain English Summary

What is this study?

• Testing a new treatment for hypertension (htn)
• NA - 70 participants
• High blood pressure (hypertension) is a leading risk factor for cardiovascular diseases and may contribute to poor health and premature death

Who can take part?

• Ages 18 Years and over
• Diagnosed with hypertension (htn)

Where?

• Newcastle upon Tyne - Northumbria University

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

High blood pressure (hypertension) is a leading risk factor for cardiovascular diseases and may contribute to poor health and premature death. The purpose of this research is to learn if a home-based isometric exercise programme combined with lifestyle change advice is a practical and acceptable method for people diagnosed with hypertension to manage their condition. Isometric exercise involves a muscle contraction without movement of the limbs and previous research has shown this may be effective for reducing blood pressure. Therefore, this study will explore the experiences, thoughts, attitudes, and barriers to participation. It will also examine the effect the isometric exercise has on blood pressure. Participants will undertake an isometric exercise programme using a wall squat position, 3 times per week, for 12 weeks. The exercise sessions will be completed at home with remote online supervision by an exercise professional. Lifestyle change advice will given in line with current guidelines to promote healthy behaviours to reduce high blood pressure. After 12 weeks, participants will be encouraged to continue with the wall squat exercise for a further 12-weeks unsupervised. Throughout the study, participants' blood pressure and daily activity will be recorded using a smartwatch device. Upon completion of the study, participants will be interviewed to gather their views and opinions on the programme. Changes in blood pressure will be evaluated at 12 and 24 weeks. By exploring whether lifestyle advice and an isometric exercise programme is a feasible and acceptable method for hypertensive people to manage their condition and how this influences blood pressure, this research may aid in the development of a strategy to manage hypertension.

Hypertension (HTN)

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What we know so far

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Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

Age: 18 Years and over
Who can join: All genders

What the study is looking for

✓Diagnosis of Arterial Hypertension (AH) in accordance with NICE guidelines.
✓Under pharmacological treatment for AH with antihypertensive drug, type and dose maintained for the previous four...
✓Blood Pressure with values \<180 and \<110 mmHg for office systolic and diastolic BP, respectively.
✓Written agreement to take part provided.

Who cannot take part

✗Body mass index \>35 kg/m2.
✗Presence of cardiovascular disease beyond hypertension.
✗Known orthopaedic, musculoskeletal, or neurological conditions that restrain isometric exercise execution.
✗Presence of secondary hypertension
✗Inability to follow verbal instructions or complete study protocol

See the full criteria

Inclusion Criteria: * Diagnosis of Arterial Hypertension (AH) in accordance with NICE guidelines. * Under pharmacological treatment for AH with antihypertensive drug, type and dose maintained for the previous four months. * Blood Pressure with values \<180 and \<110 mmHg for office systolic and diastolic BP, respectively. * Not currently engaged in any structured or supervised exercise training programme, including resistance, aerobic, or isometric exercise, defined as planned exercise performed ≥2 times per week at moderate or greater intensity, for at least three months prior to enrolment. Participants may engage in habitual physical activity; however, those meeting current physical activity recommendations (≥150 min·week-¹ of moderate-intensity or ≥75 min·week-¹ of vigorous-intensity activity, or an equivalent combination) will be excluded. Physical activity levels will be ascertained using the International Physical Activity Questionnaire (IPAQ). * Written informed consent provided. Exclusion Criteria: * Body mass index \>35 kg/m2. * Presence of cardiovascular disease beyond hypertension. * Known orthopaedic, musculoskeletal, or neurological conditions that restrain isometric exercise execution. * Presence of secondary hypertension * Inability to follow verbal instructions or complete study protocol

Where Is This Study? (1 UK site)

Northumbria University

Newcastle upon Tyne NE1 8ST, United Kingdom

Recruiting

Site contact (verified)

Helen Llewellyn, MScPrincipal Investigator

How to Get in Touch

Helen Llewellyn, MSc

Sponsor contact

CONTACT

+447587033046 helen.llewellyn@northumbria.ac.uk

Gabriel Cucato, PhD

Sponsor contact

CONTACT

gabriel.cucato@northumbria.ac.uk

Data sourced from ClinicalTrials.gov · Last verified: 2026-01