At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- INCB123667 (drug), Investigator's choice of chemotherapy (drug)
- How long the study runs
- Study runs about 41 months (dates as stated)
- About the drug or intervention
- INCB123667 — drug: Oral; tablet · Investigator's choice of chemotherapy — drug: The investigator will select the chemotherapy in accordance with the protocol-defined requirements.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- Female
- Number of participants
- 466
- Started
- 2025-12-09
- Last checked
- 2026-10
Plain English Summary
What is this study?
- • Testing a new treatment for ovarian cancer
- • Phase3 - 466 participants
- • The purpose of this study is to evaluate INCB123667 versus investigator's choice of chemotherapy in participants with platinum-resistant ovarian cancer with cyclin E1 overexpression
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with ovarian cancer
- • Female only
Where?
- • Cambridge - Addenbrooke'S Hospital - Cambridge University Hospitals Nhs Foundation Trust
- • Cardiff - Velindre Nhs Trust, Velindre Cancer Centre
- • Guildford - Royal Surrey County Hospital - Royal Surrey County Hospital Nhs Foundation Trust
- • Leeds - St James'S University Hospital - Leeds Teaching Hospitals Nhs Trust
- • +9 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The purpose of this study is to evaluate INCB123667 versus investigator's choice of chemotherapy in participants with platinum-resistant ovarian cancer with cyclin E1 overexpression.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: Female only
Biomarkers mentioned
Treatment history
Treatments you must have had:
- ✓ received at least 4 cycles of platinum containing regimen
- ✓ progressed on or within 6 months after the last dose of platinum
- ✓ bevacizumab unless there was a contraindication f
- ✓ mirvetuximab s
What the study is looking for
- ✓Histological diagnosis of high-grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer.
- ✓Have platinum-resistant disease.
- ✓Participants who have only had 1 line of platinum-based therapy must have received at least 4 cycles of platinum...
- ✓Participants who have received 2 to 4 lines of platinum-based therapy must have progressed on or within 6 months...
- ✓Archival FFPE tumor tissue block or slides from a specimen no older than 5 years must be available. If not...
Who cannot take part
- ✗Have endometrioid, clear cell, mucinous, or sarcomatous histology, mixed tumors containing any of these histologies,...
- ✗Have primary platinum-refractory disease, defined as progression on or within 3 months after the last dose of first...
- ✗Clinically significant or uncontrolled heart disease within 6 months before the first dose of study treatment.
- ✗Known active CNS metastases and/or carcinomatous meningitis.
- ✗Known additional cancer that is progressing or requires active treatment, or history of other cancer within...
See the full criteria
Where Is This Study? (13 UK sites)
Addenbrooke'S Hospital - Cambridge University Hospitals Nhs Foundation Trust
Cambridge CB2 0QQ, United Kingdom
Velindre Nhs Trust, Velindre Cancer Centre
Cardiff CF14 2TL, United Kingdom
Royal Surrey County Hospital - Royal Surrey County Hospital Nhs Foundation Trust
Guildford GU2 7XX, United Kingdom
St James'S University Hospital - Leeds Teaching Hospitals Nhs Trust
Leeds LS9 7TF, United Kingdom
Clatterbridge Cancer Center
Liverpool L7 8YA, United Kingdom
University College London Hospitals - University College London Hospitals Nhs Foundation Trust
London NW1 2BU, United Kingdom
Rajinder Sidhu - Associate Director, Research Governance and Operations
uclh.jro-communications@nhs.net020 3447 9825Guy'S Hospital - Guy'S & St Thomas' Nhs Foundation Trust
London SE1 9RT, United Kingdom
Royal Marsden Hospital - London
London SW3 6JJ, United Kingdom
The Christie Nhs Foundation Trust
Manchester Greater M204BX, United Kingdom
Northampton General Hospital - Northampton General Hospital Nhs Trust
Northampton NN1 5BD, United Kingdom
Michelle Spinks, Head of Research
ngh-tr.research.unit@nhs.net01604 545941Mount Vernon Cancer Centre
Northwood HA6 2RN, United Kingdom
Royal Marsden Hospital - Sutton
Sutton SM2 5PT, United Kingdom
Musgrove Park Hospital - Somerset Nhs Foundation Trust
Taunton TA1 5DA, United Kingdom
How to Get in Touch
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