At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Pembrolizumab (biological), Sacituzumab Tirumotecan (biological), Bevacizumab (biological), Paclitaxel (drug)
- How long the study runs
- Study runs about 69 months (dates as stated)
- About the drug or intervention
- Pembrolizumab — biological: Intravenous (IV) Infusion · Sacituzumab Tirumotecan — biological: IV Infusion · Bevacizumab — biological: IV Infusion · Paclitaxel — drug: IV Infusion · Cisplatin — drug: IV Infusion · Carboplatin — drug: IV Infusion · Rescue Medications — drug: Participants will receive the following rescue medications prior to sac-TMT infusion, per approved product label: histamine-1 receptor antagonist, histamine-2 receptor antagonist, acetaminophen or equivalent, and dexamethasone or equivalent, prophylactic steroid mouthwash (dexamethasone or equivalent), and granulocyte colony-stimulating factor (G-CSF).
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- Female
- Number of participants
- 1,023
- Started
- 2026-01-19
- Last checked
- 2026-10
Plain English Summary
What is this study?
- • Testing a new treatment for cervical cancer
- • Phase3 - 1,023 participants
- • Researchers are looking for new ways to treat metastatic cervical cancer
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with cervical cancer
- • Female only
Where?
- • Edinburgh - Western General Hospital ( Site 3604)
- • Truro - The Royal Cornwall Hospital ( Site 3606)
- • London - University College Hospital London ( Site 3605)
- • Withington - The Christie Hospital NHS Foundation Trust ( Site 3602)
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Researchers are looking for new ways to treat metastatic cervical cancer. Cervical cancer is cancer in the cervix, the lower part of the uterus (womb). Metastatic means the cancer has spread to other parts of the body. Researchers want to learn about giving the study medicine sacituzumab tirumotecan (also called sac-TMT or MK-2870) along with pembrolizumab and bevacizumab treatments. Sac-TMT is an antibody drug conjugate, which is a type of medicine that attaches to specific targets on cancer cells and delivers treatment to destroy those cells. The goals of this study are to learn: * About the safety of sac-TMT with pembrolizumab and bevacizumab, and if people tolerate them when given together, and * If people who receive sac-TMT and pembrolizumab, with or without bevacizumab, live longer overall or without their cancer getting worse as compared to those who receive standard treatment
More detail
This is a 2-part study. In Part 1 Safety Run-in, eligible participants will be allocated to treatment with sac-TMT + pembrolizumab + bevacizumab. In Part 2, all participants receive standard of care induction treatment. Eligible participants whose cancer does not progress then begin maintenance treatment and are randomized to receive pembrolizumab or sac-TMT + pembrolizumab. All participants in Part 2 maintenance treatment may also receive bevacizumab at the investigator's discretion.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: Female only
Biomarkers mentioned
Treatment history
Treatments you must have had:
- ✓ active treatment within the past 3 years
- ✓ systemic treatment in the past 2 years
What the study is looking for
- ✓The main inclusion criteria include but are not limited to the following:
- ✓Has a confirmed by a biopsy diagnosis of squamous cell carcinoma, adenosquamous carcinoma, or adenocarcinoma of...
- ✓If infected with human immunodeficiency virus (HIV), has well controlled HIV on antiretroviral therapy
- ✓If positive for hepatitis B surface antigen, has received hepatitis B virus (HBV) antiviral therapy and has...
- ✓If has a history of hepatitis C virus (HCV) infection, has undetectable HCV viral load
See the full criteria
Where Is This Study? (4 UK sites)
Western General Hospital ( Site 3604)
Edinburgh EH4 2XU, United Kingdom
The Royal Cornwall Hospital ( Site 3606)
Truro TR1 3LJ, United Kingdom
University College Hospital London ( Site 3605)
London NW1 2PG, United Kingdom
The Christie Hospital NHS Foundation Trust ( Site 3602)
Withington M20 4BX, United Kingdom
How to Get in Touch
Toll Free Number
Sponsor contactCONTACT
