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A Study to Evaluate Patient-Reported Satisfaction, Effectiveness, and Safety of Atezolizumab in Participants Treated in Routine Clinical Practice

Sponsor: Hoffmann-La Roche

NCT ID: NCT07284121

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Health checks and monitoring — no treatment given
Type of study
Observational (no treatment given)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
Atezolizumab (drug)
How long the study runs
Study runs about 41 months (dates as stated)
About the drug or intervention
Atezolizumab — drug: Atezolizumab will be administered at the discretion of the treating physician and independently of participation in this study.
Patient visit burden
Not specified by the sponsor
Type of study
Observing health over time
Ages
18 Years and over
Who
All
Number of participants
700
Started
2025-07-15
Last checked
2026-10

Plain English Summary

What is this study?

  • • Testing a new treatment for lung cancer, hepatocellular carcinoma
  • • Clinical study - 700 participants
  • • This is a non-interventional, multi-country, multi-centre, multicohort, primary data collection study, designed to assess patients' reported satisfaction with Atezolizumab Subcutenous (SC) treatment and Health-related Quality of Life (HRQoL), as well as the effectiveness and safety of Atezolizumab SC in participants treated for selected approved indications in routine clinical practice

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with lung cancer, hepatocellular carcinoma

Where?

  • • Birmingham - University Hospitals Birmingham NHS Foundation Trust
  • • Guildford - Royal Surrey County Hospital
  • • Leeds - Leeds Teaching Hosp NHS Trust
  • • Middlesbrough - James Cook University Hospital
  • • +1 more UK sites

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

This is a non-interventional, multi-country, multi-centre, multicohort, primary data collection study, designed to assess patients' reported satisfaction with Atezolizumab Subcutenous (SC) treatment and Health-related Quality of Life (HRQoL), as well as the effectiveness and safety of Atezolizumab SC in participants treated for selected approved indications in routine clinical practice.

Lung Cancer, Hepatocellular Carcinoma

How this trial compares with your answers

Answer 2 more questions to improve match

What we know so far

Condition· Matched your search
Age· Tell us your age for better matching
Gender· Tell us your sex for better matching

Still need:

  • • Tell us your age for better matching
  • • Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: All genders

Biomarkers mentioned

PD-L1EGFRALK

Treatment history

Treatments you must have had:

  • ✓ one of the following confirmed diagnoses for which atezolizumab is approved in the local SmPC:

What the study is looking for

  • ✓Participants must have one of the following confirmed diagnoses for which atezolizumab is approved in the local SmPC:
  • ✓Early stage NSCLC following complete resection and platinum-based drug treatment with a high risk of recurrence and...
  • ✓that has spread stage NSCLC with PD-L1 expression on ≥ 50% TC or ≥ 10% tumor infiltrating immune cells (IC) and with no...
  • ✓Extensive-stage small cell lung cancer (ES-SCLC) not previously treated
  • ✓Advanced or unresectable HCC not previously treated with treatment that goes through your whole body

Who cannot take part

  • ✗Not receiving treatment with Atezolizumab according to the usual treatment and in line with the current SmPC or local...
  • ✗Receiving concomitant systemic anticancer therapy at the time of initiation of Atezolizumab or an...
  • ✗Receiving treatment with Atezolizumab as part of a clinical trial, pre-approval access program, compassionate use...
  • ✗Unwilling to complete questionnaires related to treatment satisfaction and treatment-related quality of life
See the full criteria
Inclusion Criteria: * Participants must have one of the following confirmed diagnoses for which atezolizumab is approved in the local SmPC: * Early stage NSCLC following complete resection and platinum-based chemotherapy with a high risk of recurrence and PD-L1 expression on ≥ 50% of TC and with no EGFR-mutant or ALK-positive NSCLC * Metastatic stage NSCLC with PD-L1 expression on ≥ 50% TC or ≥ 10% tumor infiltrating immune cells (IC) and with no EGFR-mutant or ALK-positive NSCLC not previously treated * Extensive-stage small cell lung cancer (ES-SCLC) not previously treated * Advanced or unresectable HCC not previously treated with systemic therapy * Should not have received \> 4 prior cycles of IV Atezolizumab Exclusion Criteria: * Not receiving treatment with Atezolizumab according to standard of care and in line with the current SmPC or local labelling * Receiving concomitant systemic anticancer therapy at the time of initiation of Atezolizumab or an Atezolizumab-containing regimen for treatment of the same disease, as per label * Receiving treatment with Atezolizumab as part of a clinical trial, pre-approval access program, compassionate use program, expanded use program, post-trial access program, or continued access program * Unwilling to complete questionnaires related to treatment satisfaction and treatment-related quality of life

Where Is This Study? (5 UK sites)

University Hospitals Birmingham NHS Foundation Trust

Birmingham B15 2TH, United Kingdom

Recruiting
Hospital R&D contact (matched)

Sarah Pountain Head of Research Governance

R&D@uhb.nhs.uk0121 371 4185

Royal Surrey County Hospital

Guildford GU2 7XX, United Kingdom

Recruiting
Hospital R&D contact (matched)

Stephen Barnett

rsc-tr.ResearchAndDevelopment@nhs.net01483 688600

Leeds Teaching Hosp NHS Trust

Leeds LS9 7TF, United Kingdom

Recruiting
Hospital R&D contact (matched)

R&I Team

leedsth-tr.researchfacilitation@nhs.net0113 2060469

James Cook University Hospital

Middlesbrough TS4 3BW, United Kingdom

Recruiting
Hospital R&D contact (matched)

Research and Development

stees.dtvra@nhs.net01642 854089

James Paget University Hospitals NHS Foundation Trust

Norfolk NR31 6LA, United Kingdom

Recruiting
Hospital R&D contact (matched)

rd.office@jpaget.nhs.uk

rd.office@jpaget.nhs.uk01493 453478

How to Get in Touch

Reference Study ID Number: MO45893 https://forpatients.roche.com/ No attachments to email below.

Sponsor contact

CONTACT

888-662-6728 (U.S. and Canada) global-roche-genentech-trials@gene.com

Fastest response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry

Sponsor contact

CONTACT

Data sourced from ClinicalTrials.gov · Last verified: 2026-10