At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- MET097 (drug), Placebo (drug)
- How long the study runs
- Study runs about 28 months (dates as stated)
- About the drug or intervention
- MET097 — drug: Once-weekly MET097 administered via subcutaneous injection · Placebo — drug: Once-weekly placebo administered via subcutaneous injection
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 3,578
- Started
- 2025-12-19
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for obesity and overweight
- • Phase3 - 3,578 participants
- • This study investigates the efficacy and safety of once weekly injectable MET097 in adult participants with obesity or overweight with weight-related comorbidities excluding T2D
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with obesity and overweight
Where?
- • Sandbach - Ashfields Primary Care Center
- • Hendon - Civia Health Sunderland
- • Glasgow - FutureMeds Glasgow McCafferty House
- • Bellshill - Synexus Glasgow Clinical Research Centre
- • +20 more UK sites
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
This study investigates the efficacy and safety of once weekly injectable MET097 in adult participants with obesity or overweight with weight-related comorbidities excluding T2D. This trial will last for a duration of 84 weeks. The primary endpoint will be assessed after 64 weeks of treatment with the secondary at 84 weeks.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Who cannot take part
- ✗Have any form of diabetes
- ✗Have a self-reported body weight change \> 5 kg (11 pounds) within 3 months prior to Screening
- ✗Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
- ✗History of chronic pancreatitis or presence of acute pancreatitis within the past 180 days prior to the Screening...
See the full criteria
Where Is This Study? (24 UK sites)
Ashfields Primary Care Center
Sandbach CW11 1EQ, United Kingdom
Civia Health Sunderland
Hendon SR1 1PB, United Kingdom
FutureMeds Glasgow McCafferty House
Glasgow G20 7BE, United Kingdom
Synexus Glasgow Clinical Research Centre
Bellshill ML4 3NJ, United Kingdom
FutureMeds Birmingham
Birmingham B21 9RY, United Kingdom
Civia Health_Boots Birmingham
Birmingham B4 7TA, United Kingdom
Southmead Hospital
Bristol BS10 5NB, United Kingdom
FutureMeds Liverpool
Bromborough CH62 6EE, United Kingdom
Synexus Midlands Clinical Research Centre
Edgbaston B16 8QQ, United Kingdom
Panthera Biopartners Limited - Enfield
Enfield EN3 4GS, United Kingdom
Panthera Biopartners Limited - Glasgow
Glasgow G51 4TY, United Kingdom
Bodyline Medical Clinic, Crosby Civia Health
Liverpool L22 4QQ, United Kingdom
FutureMeds London
London NW10 2PB, United Kingdom
Synexus Manchester Clinical Research Centre
Manchester M15 6SE, United Kingdom
Kiltearn Medical Centre
Nantwich CW5 5NX, United Kingdom
FutureMeds Newcastle upon Tyne
Newcastle upon Tyne NE6 1SG, United Kingdom
Civia Health_Boots Nottingham
Nottingham NG1 3QS,, United Kingdom
Panthera Biopartners Limited - Preston
Preston PR2 9QB, United Kingdom
Panthera Biopartners Limited - Rochdale
Rochdale OL11 4AU, United Kingdom
Clifton Medical Centre
Rotherham S65 2EN, United Kingdom
Panthera Biopartners Limited - Sheffield
Sheffield S2 5FX, United Kingdom
Bodyline Medical Clinic, St Helens Civia Health
St Helens WA9 1AF, United Kingdom
FutureMeds Teesside
Stockton TS19 8PE, United Kingdom
Panthera Biopartners Limited - York
York YO24 4LJ, United Kingdom