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Looking for participantsPhase3

A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

Sponsor: Eli Lilly and Company

NCT ID: NCT07321886

View on ClinicalTrials.gov ↗

At a glance

What the study gets you
Access to the study treatment being tested
Type of study
Interventional (receives a drug or procedure)
Time in hospital
In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention
Eloralintide (drug), Placebo (drug)
How long the study runs
Study runs about 53 months (dates as stated)
About the drug or intervention
Eloralintide — drug: Administered SC · Placebo — drug: Administered SC
Patient visit burden
Not specified by the sponsor
Type of study
Testing a treatment
Ages
18 Years and over
Who
All
Number of participants
1,980
Started
2026-02-06
Last checked
2026-09

Plain English Summary

What is this study?

  • • Testing a new treatment for obesity
  • • Phase3 - 1,980 participants
  • • The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes

Who can take part?

  • • Ages 18 Years and over
  • • Diagnosed with obesity

Where?

  • • Blackpool - Layton Medical Centre
  • • Bradford on Avon - Bradford on Avon Health Centre
  • • Lancashire - Ashton Medical Group - Chapel House
  • • Lancaster - Royal Lancaster Infirmary
  • • +5 more UK sites

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

The purpose of this study is to evaluate the efficacy and safety of eloralintide in adults with obesity or overweight who do not have type 2 diabetes. The study has two phases: a main phase and an extension phase. Participation in the main phase of the study will last about 75 weeks. Participants with prediabetes will continue in the extension phase for another 2 years.

ObesityOverweight

How this trial compares with your answers

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What we know so far

Condition· Matched your search
Age· Tell us your age for better matching
Gender· Tell us your sex for better matching

Still need:

  • • Tell us your age for better matching
  • • Tell us your sex for better matching

Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

  • Age: 18 Years and over
  • Who can join: All genders

What the study is looking for

  • ✓Have Body Mass Index (BMI) at screening of the following:
  • ✓30 kilogram per square meter (kg/m2) OR
  • ✓27 kg/m2 with at least one of the following weight-related health conditions at screening:
  • ✓high blood pressure
  • ✓dyslipidemia

Who cannot take part

  • ✗Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if...
  • ✗Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy...
  • ✗Have type 1 diabetes or type 2 diabetes
  • ✗Have had within 90 days prior to screening:
  • ✗heart attack
See the full criteria
Inclusion Criteria: * Have Body Mass Index (BMI) at screening of the following: * 30 kilogram per square meter (kg/m2) OR * 27 kg/m2 with at least one of the following weight-related health conditions at screening: * high blood pressure * dyslipidemia * obstructive sleep apnea, or * heart disease * Have a stable body weight (\<5% body weight change) for 90 days prior to screening. * Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening) * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) * Have type 1 diabetes or type 2 diabetes * Have had within 90 days prior to screening: * heart attack * stroke * coronary artery revascularization * unstable angina, or * hospitalization due to congestive heart failure * Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure * Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Where Is This Study? (9 UK sites)

Layton Medical Centre

Blackpool FY3 7EN, United Kingdom

Recruiting
Site contact (verified)
Rebecca ClarkPrincipal Investigator

Bradford on Avon Health Centre

Bradford on Avon BA15 1DQ, United Kingdom

Recruiting
Site contact (verified)
Nell WyattPrincipal Investigator

Ashton Medical Group - Chapel House

Lancashire OL6 6EW, United Kingdom

Recruiting
Site contact (verified)
Omair RazzaqPrincipal Investigator

Royal Lancaster Infirmary

Lancaster LA1 4RP, United Kingdom

Recruiting
Site contact (verified)
Mohamed ElnaggarPrincipal Investigator

Altnagelvin Area Hospital

Londonderry BT47 6SB, United Kingdom

Recruiting
Site contact (verified)
Alex MirasPrincipal Investigator

Bodyline Clinic - Openshaw

Manchester M11 1AA, United Kingdom

Recruiting
Site contact (verified)
Sandra ConnellPrincipal Investigator

Wansford Research Limited

Peterborough PE8 6PL, United Kingdom

Recruiting
Site contact (verified)
Matthew DaviesPrincipal Investigator

Abbeywell Surgery

Romsey SO51 7QN, United Kingdom

Recruiting
Site contact (verified)
Nicola LesterPrincipal Investigator

Rame Group Practice

Torpoint PL11 2TB, United Kingdom

Recruiting
Site contact (verified)
Georgina HattonPrincipal Investigator

How to Get in Touch

Trial question or participation questions: 1-877-CTLILLY (1-877-285-4559) or

Sponsor contact

CONTACT

1-317-615-4559 LillyTrials@Lilly.com

Physicians interested in becoming principal investigators please contact

Sponsor contact

CONTACT

clinical_inquiry_hub@lilly.com
Data sourced from ClinicalTrials.gov · Last verified: 2026-09