At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- BI 764198 (drug), Placebo matching BI 764198 (drug)
- How long the study runs
- Study runs about 23 months (dates as stated)
- About the drug or intervention
- BI 764198 — drug: BI 764198 · Placebo matching BI 764198 — drug: Placebo matching BI 764198
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 12 Years and over
- Who
- All
- Number of participants
- 132
- Started
- 2026-03-23
- Last checked
- 2026-09
Plain English Summary
What is this study?
- • Testing a new treatment for proteinuric kidney diseases
- • Phase2 - 132 participants
- • This study is open to adults with certain kidney conditions, including secondary focal segmental glomerulosclerosis (sFSGS), treatment-resistant primary minimal change disease (TR-pMCD), Alport Syndrome (AS), and treatment-resistant primary membranous nephropathy (TR-pMN)
Who can take part?
- • Ages 12 Years and over
- • Diagnosed with proteinuric kidney diseases
Where?
- • Bradford - Bradford Institute for Health Research
- • London - The Royal London Hospital
- • London - King's College Hospital
- • Salford - Salford Royal Hospital
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
This study is open to adults with certain kidney conditions, including secondary focal segmental glomerulosclerosis (sFSGS), treatment-resistant primary minimal change disease (TR-pMCD), Alport Syndrome (AS), and treatment-resistant primary membranous nephropathy (TR-pMN). Adolescents with treatment-resistant primary MCD can also participate in this study. The purpose of this study is to find out whether a medicine called BI 764198 helps people with these kidney conditions. Participants are put into 2 groups randomly, which means by chance. One group takes BI 764198 tablets, and the other group takes placebo tablets. Placebo tablets look like BI 764198 tablets but do not contain any medicine. Participants take a tablet once a day for 20 weeks. All participants also continue their standard medication for their kidney condition during the study. Participants have twice the chance of being placed in the BI 764198 group than in the placebo group. Participants are in the study for about 7 months. During this time, they visit the study site 6 times and have 3 phone calls. Doctors regularly test the protein levels in participants' urine by collecting urine samples. They also check kidney function by taking blood samples. The results are compared between the two groups to see whether the treatment works. The doctors also regularly check participants' health and take note of any unwanted effects.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 12 Years and over
- Who can join: All genders
Biomarkers mentioned
What the study is looking for
- ✓Male or female participants ≥18 years of age (≥12 years of age for Treatment resistant primary Minimal Change...
- ✓Body Mass Index (BMI) of ≤40 kg/m2 at screening visit (Visit 1)
- ✓Weight of ≥40 kg at screening
- ✓Estimated glomerular filtration rate (eGFR) ≥25 mL/min/1.73 m2 (chronic kidney disease (CKD) EPI formula based on...
- ✓For adult participants (≥18); ≥25 mL/min/1.73 m2 (CKD-EPI formula based on serum cystatin C) at the screening visit
Who cannot take part
- ✗A history of organ transplantation or planned transplantation during the course of the study
- ✗Use of intravenous immunosuppressive agents (e.g. cyclophosphamide, rituximab, obinutuzumab) in the past 6 months...
- ✗Participants in whom initiation of oral or IV immunosuppression is anticipated during the course of the trial
- ✗Treatment with metformin or dofetilide (multidrug and toxin extrusion protein 1 (MATE1) substrates) within one week...
- ✗Treatment with strong inhibitors or strong inducers of cytochrome P450 3A4/5 (CYP3A4/5) within one week or 5...
See the full criteria
Where Is This Study? (4 UK sites)
Bradford Institute for Health Research
Bradford BD9 6RJ, United Kingdom
The Royal London Hospital
London E1 1BB, United Kingdom
King's College Hospital
London SE5 9RS, United Kingdom
Salford Royal Hospital
Salford M6 8HD, United Kingdom
How to Get in Touch
Boehringer Ingelheim
Sponsor contactCONTACT
