At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- CKD-706 (drug), US-Dupixent (drug), EU-Dupixent (drug)
- How long the study runs
- Study runs about 9 months (dates as stated)
- About the drug or intervention
- CKD-706 — drug: One subcutaneous dose of CKD-706 in pre-filled syringe, 300 mg/2mL · US-Dupixent — drug: One subcutaneous dose of US-Dupixent in pre-filled syringe, 300 mg/2mL · EU-Dupixent — drug: One subcutaneous dose of EU-Dupixent in pre-filled syringe, 300 mg/2mL
- Patient visit burden
- Not specified by the sponsor
In plain English
This study compares a new medicine called CKD-706 with Dupixent® (the brand used in the US and the brand used in Europe) in healthy adults aged 18 to 55. Researchers will look at how the drug moves through the body, its effects, how the immune system responds to it, and how safe it is. It is funded by Chong Kun Dang Pharmaceutical.
Who can take part
- Healthy adults aged 18 to 55 with suitable veins for blood samples
- Body mass index between 18.5 and 29.9, weighing at least 50 kg but under 95 kg
- Able and willing to give consent and be available for the whole study
- Women must not be pregnant or breastfeeding and must have a negative pregnancy test; men and women who can have children must use two forms of birth control
Who may not be able to
- People who have had dupilumab (Dupixent or a biosimilar) before
- Those with serious ongoing diseases, recent surgery or trauma, or planned hospital stays during the study
- Current cancer or cancer in the past 5 years, or a suspected cancer
- Weakened immune system or a serious infection within 4 weeks
- Abnormal blood tests, heart traces (ECG), or vital signs judged important by the doctor
- Positive tests for drugs of abuse or alcohol, or a history of alcohol or drug misuse
- Smoking more than 5 cigarettes a day (or equivalent nicotine, including e-cigarettes)
- Recent live vaccines or plans to have one during the study
- Positive tests for HIV, hepatitis B or hepatitis C (with some exceptions)
- Heavy coffee or caffeine use, or unwilling to avoid caffeine as required
- Blood donation of more than 500 mL in the last 56 days
- Use of most medicines, vitamins or herbal remedies from 14 days before admission until the end of the study
- Severe allergies, or allergy to antibodies or any ingredient of the study medicine
- People who cannot follow the study rules, have taken part before, are in detention or under guardianship, or are staff of the sponsor companies or study site or their close relatives
What taking part involves
- • Receiving CKD-706, US-Dupixent®, or EU-Dupixent® — Not stated — ask the trial team about how these are given and in what dose
- • Blood samples taken (participants need suitable veins for repeated samples)
- • Tests including pregnancy tests, blood tests, heart traces (ECG), and checks of vital signs
Time commitment: The exact number of visits and total study length are not stated — ask the trial team; participants must stay in the clinical unit for part of the study (an in-house stay), be available for the whole study, and follow restrictions on caffeine, smoking, and medicines.
Plain-English summary (AI-generated) from registry data. Not eligibility advice — only the trial team can confirm whether you can take part. Use the eligibility checker to see how your health profile matches this trial.
- Type of study
- Testing a treatment
- Ages
- 18 Years to 55 Years
- Who
- All
- Number of participants
- 519
- Started
- 2026-02-09
- Last checked
- 2026-01
Plain English Summary
What is this study?
- • Testing a new treatment for atopic dermatitis
- • Phase1 - 519 participants
- • This is a randomised, double-blind, three-arm, parallel group, single-dose, Phase 1 comparative study of CKD-706, US-Dupixent, and EU-Dupixent in healthy adult participants
Who can take part?
- • Ages 18 Years to 55 Years
- • Diagnosed with atopic dermatitis
Where?
- • London - Parexel EPCU London
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
This is a randomised, double-blind, three-arm, parallel group, single-dose, Phase 1 comparative study of CKD-706, US-Dupixent, and EU-Dupixent in healthy adult participants.
More detail
Dosing the CKD-706, US Dupixent, or EU-Dupixent 300 mg at Day 1. Blood samples for Pharmacokinetic analysis will be collected on Day 1 - 85. Blood sample for Pharmacodynimic and immunogenicity analysis will be collected on Day 1 - 85.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years - 55 Years
- Who can join: All genders
Biomarkers mentioned
What the study is looking for
- ✓Participant is capable of giving signed agreement to take part
- ✓Male and female healthy participant between 18 to 55 years of age (inclusive) at screening, with suitable veins for...
- ✓Body-mass index between 18.5 - 29.9 kg/m2 (inclusive) with body weight ≥ 50 kg and \< 95 kg at screening.
- ✓Participant agrees to be available for the entire duration of the study
- ✓All female participants must have a negative serum pregnancy test at the screening visit and on admission to the...
Who cannot take part
- ✗Participant with history of any clinically important disease or disorder which, may either put the participant at...
- ✗Any clinically important medical/surgical procedure or trauma within 8 weeks of the screening visit, or any planned...
- ✗Participant with prior exposure to dupilumab (Dupixent or biosimilar dupilumab).
- ✗Participation in any interventional clinical trial or receipt of any the the study treatment within 30 days (or \< 5...
- ✗Participant with current cancer or within the past 5 years and suspected cancer or undefined neoplasms.
See the full criteria
Where Is This Study? (1 UK site)
Parexel EPCU London
London HA1 3UJ, United Kingdom
How to Get in Touch
Camilla Rincon
Sponsor contactCONTACT
