At a glance
- What the study gets you
- Health checks and monitoring — no treatment given
- Type of study
- Observational (no treatment given)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Osteo Signal (device)
- How long the study runs
- Study runs about 1 month (dates as stated)
- About the drug or intervention
- Osteo Signal — device: Artificial Intelligence (AI) software
- Patient visit burden
- Not specified by the sponsor
In plain English
This study, run by Promedius Inc, is testing whether artificial intelligence (AI) software can use chest X-rays to spot signs of osteoporosis (weak or thinning bones) as well as the standard DXA scan does. It involves people aged 50 and over who have had both a chest X-ray and a DXA scan. The results of the two methods will be compared.
Who can take part
- Age 50 or older when the chest X-ray was taken
- Has had a PA (front-facing) chest X-ray and a DXA bone scan, both done within 6 months of each other, with a valid T-score from the DXA scan
- Both scans were done on or after 1 January 2010
- Sex and age details are available on hospital records or the imaging system (PACS)
- Has not opted out of their confidential data being used for research
Who may not be able to
- Scans that are poor quality or incomplete, in the wrong format, or where the chest X-ray was more than 6 months before or after the DXA scan
- Already diagnosed with osteoporosis (a T-score of -2.5 or lower) or taking osteoporosis medicines before or around the time of the study scans
- Diagnosed with any metabolic bone disease before, or up to 3 months after, the DXA scan used in the study
- Major chest wall or spinal problems, such as severe curvature of the spine, chest wall deformities affecting more than 30% of the chest area, metal implants from chest or spine surgery, or lung problems covering more than 30% of the bones seen on the X-ray
What taking part involves
- • No new treatment is given — the study looks at scans and data that have already been collected
Time commitment: No new scans or visits are described — the study uses chest X-rays and DXA scans already performed on or after 1 January 2010.
Plain-English summary (AI-generated) from registry data. Not eligibility advice — only the trial team can confirm whether you can take part. Use the eligibility checker to see how your health profile matches this trial.
- Type of study
- Observing health over time
- Ages
- 50 Years and over
- Who
- All
- Number of participants
- 595
- Started
- 2026-02-10
- Last checked
- 2026-02
Plain English Summary
What is this study?
- • Testing a new treatment for osteoporosis, osteopenia
- • Clinical study - 595 participants
- • The goal of this study is to assess the performance of an artificial intelligence software (Osteo Signal) in detecting osteoporosis risk in adults 50 years and older
Who can take part?
- • Ages 50 Years and over
- • Diagnosed with osteoporosis, osteopenia
Where?
- • Westcliff-on-Sea - Mid and South Essex NHS Foundation Trust
- • London - Barts Health NHS Trust
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The goal of this study is to assess the performance of an artificial intelligence software (Osteo Signal) in detecting osteoporosis risk in adults 50 years and older. The main question it aims to answer is: What is the accuracy of the software in detecting osteoporosis risk on chest x-ray images as compared to the standard technique of dual-energy x-ray absorptiometry (DXA)? There is no direct involvement of participants in this study as it will use data from individuals who have already had a chest x-ray and a DXA scan taken in the past.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 50 Years and over
- Who can join: All genders
What the study is looking for
- ✓Age ≥50 years at the time of chest X-ray
- ✓Availability of
- ✓Posteroanterior (PA) Chest X-ray and
- ✓DXA scan with a valid T-score measurement where both the DXA scan and Chest x-ray examinations were performed within...
- ✓Available X-ray and DXA scans performed on or after 01-Jan-2010.
Who cannot take part
- ✗Non-diagnostic Quality or Incomplete Imaging of:
- ✗DXA scan inadequacy: Missing T-score from a technically inadequate scan.
- ✗PA Chest X-ray technical inadequacy: Non-PA projection, significant motion artefacts, inadequate visualisation of...
- ✗Image format incompatibility: Non-DICOM format or corrupted image files that would prevent AI analysis
- ✗PA Chest X-ray \> ±6 months from the date of the DXA scan.
See the full criteria
Where Is This Study? (2 UK sites)
Mid and South Essex NHS Foundation Trust
Westcliff-on-Sea SS0 0RY, United Kingdom
Barts Health NHS Trust
London E1 4DG, United Kingdom
How to Get in Touch
Kim Bensalem
Sponsor contactCONTACT
Jung Jinho
Sponsor contactCONTACT