At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Fluoxetine (drug), Placebo (drug)
- How long the study runs
- Study runs about 14 months (dates as stated)
- About the drug or intervention
- Fluoxetine — drug: Participants will receive 20mg of fluoxetine daily for 7 days. · Placebo — drug: Participants will receive one dose placebo (sucrose) daily for 7 days.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years to 24 Years
- Who
- All
- Number of participants
- 80
- Started
- 2025-10-01
- Last checked
- 2025-09
Plain English Summary
What is this study?
- • Testing a new treatment for depression - major depressive disorder
- • NA - 80 participants
- • The goal of this clinical medicine study is to investigate how does antidepressant fluoxetine modulate anger processing in healthy young people
Who can take part?
- • Ages 18 Years to 24 Years
- • Diagnosed with depression - major depressive disorder
Where?
- • Oxford - Department of Psychiatry, University of Oxford
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The goal of this clinical medicine study is to investigate how does antidepressant fluoxetine modulate anger processing in healthy young people . The main questions it aims is to answer are: 1. How does fluoxetine affect responses to anger-related stimuli such as words, faces, and autobiographical recall? 2. How does fluoxetine influence responses during frustration induction in frustrative non-reward and threat paradigms? 3. Does the effect manifest in physiological markers, including heart rate variability and facial expressions? Researchers will compare fluoxetine to a placebo to see if drug fluoxetine affects anger processing. Participants will: Take 20mg fluoxetine or a placebo every day for 7 days. Visit the university site for questionnaire and tasks assessments. Heart rate variability and facial expressions will be recorded in some of the tasks.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years - 24 Years
- Who can join: All genders
What the study is looking for
- ✓Be aged 18-24 years (inclusive)
- ✓Be resident in the UK for the duration of the study
- ✓Have normal or corrected to normal vision
- ✓Participant is willing and able to give agreement to take part for participation in the research
- ✓Sufficiently fluent English to understand and complete the study
Who cannot take part
- ✗The participant may not enter the study if ANY of the following apply:
- ✗Psychiatric History:
- ✗First degree relative with a diagnosis of mania;
- ✗Lifestyle:
- ✗Heavy smoker or vaper (\> 10 cigarettes per day, or \>2 mL e-liquid, or \>15mg/day from a nicotine patch);
See the full criteria
Where Is This Study? (1 UK site)
Department of Psychiatry, University of Oxford
Oxford OX3 7JX, United Kingdom
How to Get in Touch
Catherine Harmer, PhD
Sponsor contactCONTACT
Ye Wo, MSc
Sponsor contactCONTACT
