At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Biventricular pacing (device), Conduction system pacing (device), Left bundle optimised cardiac resynchronisation therapy (device)
- How long the study runs
- Study runs about 35 months (dates as stated)
- About the drug or intervention
- Biventricular pacing — device: Cardiac resynchronisation therapy with one lead to right ventricular endocardium and one lead to left ventricular epicardium, accessed via the coronary sinus. · Conduction system pacing — device: Cardiac resynchronisation therapy with single lead targeting direct capture of the conduction system. · Left bundle optimised cardiac resynchronisation therapy — device: Cardiac resynchronisation therapy delivered by conduction system optimised hybrid configurations.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 60
- Started
- 2025-11-12
- Last checked
- 2026-02
Plain English Summary
What is this study?
- • Testing a new treatment for heart failure and reduced ejection fraction
- • NA - 60 participants
- • The goal of this clinical trial is to find out which type of specialist pacemaker-known as cardiac resynchronisation therapy (CRT)-works best for people with heart failure and a delay in how the lower chambers of the heart beat together (called electrical dyssynchrony)
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with heart failure and reduced ejection fraction
Where?
- • London - Hammersmith Hospital, Imperial College Healthcare NHS Trust
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
The goal of this clinical trial is to find out which type of specialist pacemaker-known as cardiac resynchronisation therapy (CRT)-works best for people with heart failure and a delay in how the lower chambers of the heart beat together (called electrical dyssynchrony). The main aims of the study are: To compare the effects of conventional biventricular pacing (BVP), conduction system pacing (CSP) and left-bundle optimised CRT (LOT-CRT) on heart failure symptoms and heart rhythm problems over six months. To explore how these pacing methods affect heart muscle strength, electrical activity, and overall heart function. Participants will: Attend four hospital visits over a six-month period. At Visit 1, meet a member of the research team to discuss the study and have screening tests to check eligibility. Participants will also have a smartphone app installed and receive training on how to record their daily heart failure symptoms. At Visit 2, have a CRT pacemaker implanted. The type of pacemaker will be chosen at random, with a 1 in 3 chance of receiving: * Biventricular pacing (BVP); the current standard treatment * Conduction system pacing (CSP) * LOT-CRT (Left-bundle optimised CRT); a combination of both At Visit 3 (around 12 weeks after implantation) and Visit 4 (6 months after implantation), take part in routine follow-up assessments to check the pacemaker and heart function. At Visits 2 and 4, also undergo non-invasive electrical mapping tests, including wearing a specialised vest and having a low-dose CT scan of the chest. These tests help researchers understand how the heart's electrical system responds to different pacing methods.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Biomarkers mentioned
What the study is looking for
- ✓Patients referred/scheduled for a CRT procedure (new implant or upgrade) who have:
- ✓causing symptoms heart failure (NYHA II-IV)
- ✓Reduced ejection fraction (LVEF≤40%)
- ✓Prolonged QRS duration (≥130ms) and left bundle branch block ECG morphology or very prolonged QRS duration (\>150ms)...
- ✓Optimal medical therapy for HF
Who cannot take part
- ✗Unable to provide agreement to take part
- ✗\<18 years old
- ✗Pregnant patients (with female patients of childbearing age requiring a negative urine BHCG)
See the full criteria
Where Is This Study? (1 UK site)
Hammersmith Hospital, Imperial College Healthcare NHS Trust
London W12 0HS, United Kingdom
How to Get in Touch
Jack W Samways, MBChB, MRes, MRCP
Sponsor contactCONTACT