At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- low intensity of CRRT (procedure), usual intensity of CRRT (procedure)
- How long the study runs
- Study runs about 25 months (dates as stated)
- About the drug or intervention
- low intensity of CRRT — procedure: usual intensity CRRT · usual intensity of CRRT — procedure: usual intensity
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 20
- Started
- 2025-02-15
- Last checked
- 2026-03
Plain English Summary
What is this study?
- • Testing a new treatment for acute kidney injury (nontraumatic)
- • NA - 20 participants
- • Acute kidney injury is a potentially life threatening condition which affects 1 in 2 patients in the Intensive Care Unit (ICU)
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with acute kidney injury (nontraumatic)
Where?
- • London - Guy's & St Thomas' Hospital
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Acute kidney injury is a potentially life threatening condition which affects 1 in 2 patients in the Intensive Care Unit (ICU). Patients often need dialysis treatment, also called renal replacement therapy. Renal replacement therapy is a treatment that removes toxins and excess fluid from the blood stream. It consists of having a small plastic catheter in a vein in the neck or in the groin through which blood flows through a dialysis machine and is cleansed and excess water is removed. The cleansed blood is then returned to the patient via the same catheter. One of the major areas of uncertainty for doctors in the ICU is "What is the right intensity of renal replacement therapy for patients with acute kidney injury?" A higher intensity indeed removes more toxins but also removes other substances in the blood, including vitamins, nutrients and important medications. The current usual dose is around 25 ml/kg/hr but clinical practice in the UK is very variable and some patients routinely receive higher doses and some get lower doses. Data from large databases worldwide have suggested that a lower dose is safe and effective and may potentially allow the kidneys to recover faster but confirmation is lacking. In this study, the investigators investigate whether renal replacement therapy at a lower intensity is as effective and safe as currently used doses. Participants will be randomised to receiving renal replacement therapy at usual or lower intensity. There will be no change to any other aspects of treatment. The results will inform the investigators whether the study protocol is feasible and how best to design a future larger research study.
More detail
Acute kidney injury is a potentially life threatening condition which affects 1 in 2 patients in the Intensive Care Unit (ICU). Patients often need dialysis treatment, also called renal replacement therapy. Renal replacement therapy is a treatment that removes toxins and excess fluid from the blood stream. It consists of having a small plastic catheter in a vein in the neck or in the groin through which blood flows through a dialysis machine and is cleansed and excess water is removed. The cleansed blood is then returned to the patient via the same catheter. One of the major areas of uncertainty for doctors in the ICU is "What is the right intensity of renal replacement therapy for patients with acute kidney injury?" A higher intensity indeed removes more toxins but also removes other substances in the blood, including vitamins, nutrients and important medications. The current usual dose is around 25 ml/kg/hr but clinical practice in the UK is very variable and some patients routinely receive higher doses and some get lower doses. Data from large databases worldwide have suggested that a lower dose is safe and effective and may potentially allow the kidneys to recover faster but confirmation is lacking. In this study, the investigators investigate whether renal replacement therapy at a lower intensity is as effective and safe as currently used doses. Participants will be randomised to receiving renal replacement therapy at usual or lower intensity. There will be no change to any other aspects of treatment. The investigators aim to recruit 20 patients in the UK. Fully anonymised results will be shared with researchers in Canada who are conducting the same study.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
What the study is looking for
- ✓age ≥ 18 years
- ✓patient weight ≥ 55 kg
- ✓plan to start CRRT or within 24 hours of having started CRRT for AKI
- ✓expected to survive and receive CRRT for a duration of ≥ 48 hours
Who cannot take part
- ✗indication for sustained higher dose-intensity CRRT
- ✗end-stage kidney disease receiving maintenance dialysis
- ✗previous receipt of RRT for AKI during the current hospitalization
- ✗inability to comply with the requirements of the study protocol
See the full criteria
Where Is This Study? (1 UK site)
Guy's & St Thomas' Hospital
London SE1 7EH, United Kingdom
How to Get in Touch
Marlies Ostermann, PhD
Sponsor contactCONTACT
Gillian Radcliffe
Sponsor contactCONTACT