At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Pyridoxal-5'-Phosphate supplement (drug), Placebo Supplementation (drug)
- How long the study runs
- Study runs about 6 months (dates as stated)
- About the drug or intervention
- Pyridoxal-5'-Phosphate supplement — drug: 100mg PLP in the form of a tablet, taken once a day for 1 week · Placebo Supplementation — drug: Placebo supplement in the form of a capsule.
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years to 41 Years
- Who
- All
- Number of participants
- 44
- Started
- 2026-03-23
- Last checked
- 2026-10
Plain English Summary
What is this study?
- • Testing a new treatment for neural inhibition
- • NA - 44 participants
- • This clinical trial investigates the effects of Vitamin B6 supplementation on neural inhibition using electroencephalography (EEG), in relation to depression and anxiety symptoms in participants from the general population with a relatively high level of symptoms at baseline
Who can take part?
- • Ages 18 Years to 41 Years
- • Diagnosed with neural inhibition
Where?
- • Reading - Harry Pitt Building
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
This clinical trial investigates the effects of Vitamin B6 supplementation on neural inhibition using electroencephalography (EEG), in relation to depression and anxiety symptoms in participants from the general population with a relatively high level of symptoms at baseline. Researchers will compare a placebo group to high-dose Vitamin B6 to test the hypothesis that Vitamin B6 moves the excitation/inhibition balance towards inhibition.
More detail
The primary question this trial aims to answer is: \- Compared to placebo, in people experiencing depression and anxiety symptoms, does high-dose Vitamin B6 supplementation change the excitation/inhibition balance towards inhibition as measured using electroencephalography (EEG)? Secondary research questions are: * Compared to placebo, does high-dose Vitamin B6 supplementation reduce symptoms of depression and anxiety? * Do individuals with lower Vitamin B6 levels at baseline, as measured in blood plasma, show a larger effect of high dose Vitamin B6 on the EEG measures or symptoms? * Compared to placebo, does high-dose Vitamin B6 intervention lead to an increase in hand grip strength? This is a possibility suggested to us by our prvious finding of reduced self reported 'postural disorder' by Vitamin B6 (Field et al., 2024), and by existing literature about the role of Vitamin B6 in muscle function.
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years - 41 Years
- Who can join: All genders
What the study is looking for
- ✓Over 18 years of age and under 41
- ✓Mild to moderate anxiety and/or depression
- ✓Normal or corrected to normal vision
Who cannot take part
- ✗not taking daily dietary supplement containing \>2 mg Vitamin B6
- ✗not taking medication that is a GABA agaonist (our team will check this with you)
- ✗not be pregnant
- ✗no medical history of epilepsy
- ✗no medical history of peripheral neuropathy
See the full criteria
Where Is This Study? (1 UK site)
Harry Pitt Building
Reading RG6 6ES, United Kingdom