At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Control (supplement), Intervention (supplement)
- How long the study runs
- Study runs about 17 months (dates as stated)
- About the drug or intervention
- Control — supplement: Identical maltodextrin tablet. · Intervention — supplement: 1,000 mg Vitamin C and 400 mg non-steroidal anti-inflammatory drug every 8-h for 48-h
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years to 45 Years
- Who
- All
- Number of participants
- 52
- Started
- 2025-09-01
- Last checked
- 2026-02
Plain English Summary
What is this study?
- • Testing a new treatment for exercise recovery
- • NA - 52 participants
- • Eccentric exercise, particularly when novel and strenuous, can cause soreness and inflammation, impairing subsequent exercise performance
Who can take part?
- • Ages 18 Years to 45 Years
- • Diagnosed with exercise recovery
Where?
- • Bath - University of Bath
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
Eccentric exercise, particularly when novel and strenuous, can cause soreness and inflammation, impairing subsequent exercise performance. These performance decrements are attributable to oxidative stress and inflammation. Interestingly, a single bout of eccentric exercise can confer protective effects, ameliorating the negative consequences in subsequent bouts. This is termed the repeated bout effect (RBE), which would be of interest to athletes considering the detrimental effects of strenuous eccentric exercise. Athletes regularly consume supplements in hope of attenuating the performance decrements after strenuous eccentric exercise . However, considering the dose-response relationship between the initial performance decrement and the magnitude of the RBE , supplements may diminish the obtainment of the RBE. This notion remains untested, and so the proposed project is a double-blind, placebo-controlled, parallel group study aiming to assess the effects of acute vitamin C and ibuprofen supplementation on the development of the RBE. These two supplements were chosen as they are most frequently and successfully used in the literature to target oxidative stress (vitamin C) and inflammation (ibuprofen). Additionally, these doses (and the timing of supplements) were chosen to mimic protocols reporting beneficial effects
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years - 45 Years
- Who can join: All genders
What the study is looking for
- ✓18 - 45 years of age
- ✓BMI 18.5 - 29.9 kg/m2
- ✓Able to perform 20-minutes of bench stepping exercise
- ✓Capable and willing to provide consent (oral and written)
Who cannot take part
- ✗Familiarised with bench stepping exercise procedures
- ✗Not cleared for exercise by health questionnaires or physical activity readiness questionnaire
- ✗Participants exhibiting any alteration in clinical inflammation parameters due to other cause
- ✗Participants currently being prescribed any anti-inflammatory medications
See the full criteria
Where Is This Study? (1 UK site)
University of Bath
Bath, United Kingdom