At a glance
- What the study gets you
- Access to the study treatment being tested
- Type of study
- Interventional (receives a drug or procedure)
- Time in hospital
- In-person visits at study sites — visit count not specified by the sponsor
- Drug or intervention
- Obicetrapib 10 mg/Bempedoic Acid Placebo (drug), Bempedoic Acid 180mg/Placebo Obicetrapib (drug)
- How long the study runs
- Study runs about 8 months (dates as stated)
- About the drug or intervention
- Obicetrapib 10 mg/Bempedoic Acid Placebo — drug: Orally, Once Daily · Bempedoic Acid 180mg/Placebo Obicetrapib — drug: Orally, Once Daily
- Patient visit burden
- Not specified by the sponsor
- Type of study
- Testing a treatment
- Ages
- 18 Years and over
- Who
- All
- Number of participants
- 426
- Started
- 2026-05-06
- Last checked
- 2026-04
Plain English Summary
What is this study?
- • Testing a new treatment for mixed dyslipidemia
- • Phase3 - 426 participants
- • This Phase 3, randomized, double-blind, active-controlled study evaluates the efficacy and safety of obicetrapib (OBI) compared to bempedoic acid (BPA) in participants with dyslipidemia at high or very high cardiovascular risk
Who can take part?
- • Ages 18 Years and over
- • Diagnosed with mixed dyslipidemia
Where?
- • Stockton-on-Tees - FutureMeds North Tees
This is a simplified summary. Always discuss with your doctor before making any decisions.
About This Trial
This Phase 3, randomized, double-blind, active-controlled study evaluates the efficacy and safety of obicetrapib (OBI) compared to bempedoic acid (BPA) in participants with dyslipidemia at high or very high cardiovascular risk. Participants must have elevated low density lipoprotein cholesterol (LDL-C) levels despite receiving maximally tolerated lipid lowering therapy. The primary objective is to compare the LDL-C lowering effect of OBI (a CETP inhibitor) against BPA at 12 weeks
How this trial compares with your answers
Answer 2 more questions to improve match
What we know so far
Still need:
- • Tell us your age for better matching
- • Tell us your sex for better matching
Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.
Eligibility at a Glance
Key info
- Age: 18 Years and over
- Who can join: All genders
Biomarkers mentioned
What the study is looking for
- ✓Are male or female and ≥18 years of age at Screening (Visit 1);
- ✓Females may be enrolled if all 3 of the following criteria are met:
- ✓Are not pregnant;
- ✓Are not breastfeeding; and
- ✓Do not plan to become pregnant during the study.
Who cannot take part
- ✗Have current or any previous history of New York Heart Association class III or IV HF or left ventricular ejection...
- ✗Have been hospitalized for HF, with HF as the primary cause of the hospitalization, within 5 years prior to...
- ✗Have uncontrolled severe hypertension;
- ✗Have a formal diagnosis of definite familial hypercholesterolemia (either homozygous or heterozygous) either through...
- ✗Have active liver disease;
See the full criteria
Where Is This Study? (1 UK site)
FutureMeds North Tees
Stockton-on-Tees TS19, United Kingdom
Research and Development
nth-tr.ntandh.researchdevelopment@nhs.net01642 624090How to Get in Touch
Andrea Conte, Medical Doctor
Sponsor contactCONTACT
