UK clinical trials - updated daily from ClinicalTrials.gov
Find clinical trials for Crohn's disease in the United Kingdom. Explore treatment pathways from first-line to advanced biologic therapy.
Crohn's disease is a type of inflammatory bowel disease (IBD) affecting ~115,000 people in the UK. It can affect any part of the digestive tract from mouth to anus. Symptoms include abdominal pain, diarrhoea, weight loss, and fatigue. Treatment aims to induce and maintain remission.
First-line: corticosteroids to control flares, then immunosuppressants (azathioprine, methotrexate) or biologics to maintain remission. Biologic therapies include anti-TNF (infliximab, adalimumab), anti-integrin (vedolizumab), and anti-IL-23 (risankizumab, ustekinumab). JAK inhibitors (tofacitinib, upadacitinib) are newer oral options.
The UK is a leader in IBD research. Current trials: next-generation biologics, oral small molecules, microbiome therapies (faecal transplant), precision medicine approaches based on genetics, and surgical innovations. Most trials are available through NHS gastroenterology centres.
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