UK clinical trials - updated daily from ClinicalTrials.gov
Find clinical trials for rheumatoid arthritis in the United Kingdom. Explore treatment pathways including DMARDs, biologics, and JAK inhibitors.
Rheumatoid arthritis affects over 430,000 adults in the UK. It is an autoimmune condition where the immune system attacks the joints, causing pain, swelling, and progressive joint damage. Modern treatment aims for remission or low disease activity using a "treat-to-target" approach. Early treatment (within 3 months of symptom onset) significantly improves long-term outcomes.
First-line: methotrexate (DMARD) ± short-term steroids. If inadequate response: add a biologic DMARD - anti-TNF (adalimumab, etanercept), anti-IL-6 (tocilizumab, sarilumab), anti-CD20 (rituximab), or CTLA-4 (abatacept). If biologics fail: JAK inhibitors (tofacitinib, baricitinib, upadacitinib) are oral alternatives. NICE recommends cycling through mechanisms of action. Target is DAS28 < 2.6 (remission).
Active UK RA trials include: next-generation targeted therapies, biosimilar switching studies, precision medicine (matching treatment to genetic/serological profile), remission induction strategies, and digital health tools for remote monitoring. Versus Arthritis and the NHS support a strong UK rheumatology research infrastructure.
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