UK clinical trials - updated daily from ClinicalTrials.gov
Find clinical trials for hypertension (high blood pressure) in the United Kingdom. Explore treatment pathways including lifestyle interventions, medications, and device-based therapies.
Hypertension affects ~14 million people in the UK (~1 in 3 adults). It is the single biggest risk factor for heart disease, stroke, and kidney failure worldwide. Often called the silent killer because it has no symptoms until significant damage has occurred. The NHS Health Check programme detects many cases early. Target blood pressure is below 140/90 mmHg (or 130/80 mmHg for those with diabetes, kidney disease, or cardiovascular disease).
First-line: lifestyle - reduce salt (<6g/day), exercise (150 min/week), weight loss, limited alcohol. Drug A (age <55): ACE inhibitor (ramipril, lisinopril) or ARB (losartan, candesartan). Drug B (age >55 or black African/Caribbean): calcium channel blocker (amlodipine). Step 3: A + C + thiazide diuretic (indapamide). Resistant hypertension (4+ drugs): add spironolactone or alpha-blocker (doxazosin). NICE guidelines are globally recognised.
For resistant hypertension (persistently >140/90 mmHg despite 3+ medications), renal denervation (RDN) is a groundbreaking procedure - a catheter ablates renal artery nerves to reduce sympathetic nervous system activation. The SPYRAL HTN and RADIANCE-HTN trials confirmed its efficacy. Baroreflex activation (Rheos system) and central arteriovenous fistula coupling are other device-based approaches under investigation.
Active UK hypertension trials include: next-generation mineralocorticoid receptor antagonists (finerenone, esaxerenone), dual angiotensin receptor-neprilysin inhibitors (ARNIs like sacubitril/valsartan), renal denervation in earlier-stage hypertension, wearable blood pressure monitoring, digital therapeutic programmes (NHS-approved apps), and personalised medicine approaches using genetic and biomarker profiling. The British Hypertension Society and NIHR fund extensive UK research.
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