UK clinical trials - updated daily from ClinicalTrials.gov
Find clinical trials for infectious diseases in the United Kingdom. Explore vaccine studies, challenge trials, and treatment research for COVID-19, influenza, RSV, and more.
The UK is a world leader in infectious disease research, with dedicated facilities including hVIVO's challenge study units, the NIHR Vaccine Research Centres, and university microbiology departments. Human challenge trials — where healthy volunteers are deliberately exposed to viruses under controlled conditions — are a unique UK strength. These studies offer some of the highest compensation in clinical research (£2,000-£5,000+) due to the residential quarantine requirements.
The UK played a central role in COVID-19 vaccine development (Oxford-AstraZeneca) and continues to lead in vaccine research for flu, RSV, malaria, tuberculosis, and pandemic preparedness. Phase 1 vaccine trials typically recruit healthy volunteers aged 18-55 and involve multiple outpatient visits over several months. Compensation ranges from £500-£2,000. Challenge vaccine trials involve residential stays and pay significantly more.
Human challenge studies are unique to the UK. Volunteers are exposed to controlled doses of viruses (flu, common cold, RSV, COVID-19) in specialist quarantine facilities. These studies require 10-15 day residential stays with full board, entertainment, and medical supervision. Compensation: £3,000-£5,000+. FluCamp (hVIVO) in London is the primary facility, with screening centres in London and Manchester.
Active UK infectious disease trials include: next-generation COVID-19 vaccines (mRNA, protein subunit, intranasal), universal flu vaccines, RSV prevention studies, antimicrobial resistance research, long COVID treatment trials, tuberculosis vaccine development, and HIV cure research. Many Phase 1 studies accept healthy volunteers and offer compensation.
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