UK clinical trials - updated daily from ClinicalTrials.gov
Find vaccine clinical trials in the United Kingdom. Explore paid healthy volunteer studies for flu, COVID-19, RSV, and experimental vaccines — including challenge trials.
The UK is a global powerhouse in vaccine research. The Oxford-AstraZeneca COVID-19 vaccine saved millions of lives worldwide. The UK's National Institute for Health Research (NIHR) runs dedicated Vaccine Research Centres, and facilities like hVIVO's FluCamp specialise in human challenge trials where volunteers are exposed to viruses to test vaccines. These challenge studies are among the highest-paid clinical trials available, with compensation of £3,000-£5,000+ for residential stays.
Phase 1 safety studies: small groups of healthy volunteers test new vaccines for safety and immune response. Typically 3-10 outpatient visits over 6-12 months. Compensation: £500-£2,000. Phase 2/3 efficacy trials: larger groups including at-risk populations. Challenge trials: healthy volunteers are exposed to the target virus after vaccination to prove the vaccine works. These require 10-15 day residential quarantine with full facilities. Compensation: £3,000-£5,000+. Bioequivalence studies: comparing generic or biosimilar vaccines. Compensation: £500-£2,000.
Active UK vaccine research includes: universal flu vaccines (targeting conserved viral proteins for broader protection), next-generation COVID-19 vaccines (mRNA updates, intranasal vaccines, pan-coronavirus approaches), RSV vaccines for all ages, tuberculosis vaccines (M72/AS01E in Phase 3), malaria vaccines (building on RTS,S/AS01), HIV vaccines, cancer vaccines (personalised mRNA), and pandemic preparedness platforms.
Vaccine trials recruit through NHS trusts, university research units, and commercial Phase 1 units. Key UK sites: hVIVO/FluCamp (London), Clinical Research Centres at Oxford, Cambridge, Imperial, UCL, Southampton, and Liverpool. Most Phase 1 vaccine studies require healthy adults aged 18-55, though some target older adults (65+) or specific risk groups. Screening is thorough — medical history, blood tests, and sometimes ECG. Travel expenses are typically reimbursed on top of compensation.
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